Lista completa de Publicações

@article{Mastrobuono-Cordeiro2026,

title = {Synthesis, structural characterization and biological evaluation of silver(I) complexes with 2-thiouracil and 2,4-dithiouracil},

author = {Francisco Mastrobuono-Cordeiro and Julia H. Bormio Nunes and Gabriele de M. Pereira and Douglas H. Nakahata and Silmara C.L. Frajácomo and Wilton R. Lustri and João Ernesto de Carvalho and Douglas H. Pereira and Ana Lúcia T.G. Ruiz and Raphael E.F. de Paiva and Pedro P. Corbi},

doi = {10.1016/j.ica.2025.122971},

issn = {0020-1693},

year  = {2026},

date = {2026-01-00},

urldate = {2026-01-00},

journal = {Inorganica Chimica Acta},

volume = {590},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{deLacerda2026b,

title = {A new palladium(II) complex containing ethylenediamine and 2-thioxo-4-thiazolidinone exhibits high activity against resistant Campylobacter jejuni strains},

author = {Meiry Leandra de Lacerda and Letícia Roberta Martins Costa and Dayanne Maria da Silva Coimbra and Gabriele de Menezes Pereira and Clara Maria Faria Silva and Pedro Paulo Corbi and Daise Aparecida Rossi and Robson José de Oliveira Júnior and Roberta Torres de Melo and Wendell Guerra},

doi = {10.1016/j.ica.2025.122913},

issn = {0020-1693},

year  = {2026},

date = {2026-01-00},

urldate = {2026-01-00},

journal = {Inorganica Chimica Acta},

volume = {589},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Souza2025,

title = {Brazilian profile of Radium-223 in metastatic prostate cancer: a multicentric, retrospective study},

author = {Stephan Souza and Felipe Ribeiro and Ana Brito and Thaís Minekawa and Flávia Lopes and Sumara Matedi and Renata Fockink and Dalton Anjos and Gustavo Gomes and Laura Silva and Mariana Camacho and Allan Santos and Whemberton Araújo and Ana Teixeira and Raul Martins and Adelina Sanches and Nilton Hanaoka and Rafael Tavares and Felipe Villela-Pedras and Felipe Mourato and Caroline Torricelli and Thiago Alves and Marcelo Tavares and Mariana Lima and André Moraes and André Sasse and Paulo Almeida and Elba Etchebehere},

doi = {10.1186/s41824-025-00245-9},

issn = {3005-074X},

year  = {2025},

date = {2025-12-00},

urldate = {2025-12-00},

journal = {EJNMMI Rep.},

volume = {9},

number = {1},

publisher = {Springer Science and Business Media LLC},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Coelho2025,

title = {Exploring biological properties of sulfa-based copper(II) complexes: in vitro genotoxicity, cytotoxicity (2D and 3D) and mechanistic insights},

author = {Maria Paula M. Coelho and Gabriele de Menezes Pereira and Pedro Paulo Corbi and Douglas H. Nakahata and Valentina Gandin and Chiara Donati and Juliana F. Vecina and Ana Lucia T. G. Ruiz},

doi = {10.1007/s10534-025-00719-0},

issn = {1572-8773},

year  = {2025},

date = {2025-10-00},

urldate = {2025-10-00},

journal = {Biometals},

volume = {38},

number = {5},

pages = {1551--1567},

publisher = {Springer Science and Business Media LLC},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Carrilho2025b,

title = {Prognostic impact of low muscularity in metastatic and recurrent head and neck cancer: Insights from C3-based assessments},

author = {Larissa Ariel Oliveira Carrilho and Livia Dias Guerra and Rafaella Caroline de Lellis Moreira and Fabiana Lascala Juliani and Fernanda Silva Santos and Daniela Morais de Holanda Padilha and Fabíola Furtuoso Zaperlão and Sandra Regina Branbilla and Vivian Naomi Horita and Davi Magalhães Leite Novaes and Lígia Moraes Antunes-Correa and Carmem Silvia Passos Lima and Maria Carolina Santos Mendes and José Barreto Campello Carvalheira},

doi = {10.1016/j.clnesp.2025.06.029},

issn = {2405-4577},

year  = {2025},

date = {2025-08-00},

urldate = {2025-08-00},

journal = {Clinical Nutrition ESPEN},

volume = {68},

pages = {767--773},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Nakahata2025,

title = {Pd(II) complexes of 4-(2-aminoethyl)benzenesulfonamide Schiff bases: Structure, DNA binding and antiproliferative activity},

author = {Douglas H. Nakahata and Gabriele de M. Pereira and Marcos A. Ribeiro and Igor S. Oliveira and Josélia C. de Oliveira Moreira and Robson Pontes and João E. de Carvalho and Ana Lucia T.G. Ruiz and Nicholas P. Farrell and Pedro P. Corbi},

doi = {10.1016/j.ica.2025.122659},

issn = {0020-1693},

year  = {2025},

date = {2025-06-00},

urldate = {2025-06-00},

journal = {Inorganica Chimica Acta},

volume = {581},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Pereira2025,

title = {Evaluation of quality parameters, physicochemical and bioactive properties of licuri oil (Syagrus coronata)},

author = {Gabriel Sthefano Lourenço Pereira and Patrícia Tonon de Souza and Grace Kelly Mizuno Flozino and Rafael Fernandes Almeida and Dhayna Oliveira Sobral and Marcelo Antonio Morgano and Wilton Rogério Lustri and Silmara Cristina Lazarini and Pedro Paulo Corbi and Antonio José de Almeida Meirelles and Guilherme José Maximo and Eduardo Augusto Caldas Batista and Klicia Araujo Sampaio},

doi = {10.1016/j.foodres.2025.116157},

issn = {0963-9969},

year  = {2025},

date = {2025-05-00},

urldate = {2025-05-00},

journal = {Food Research International},

volume = {208},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Carrilho2025,

title = {Adipose tissue characteristics as a new prognosis marker of patients with locally advanced head and neck cancer},

author = {Larissa Ariel Oliveira Carrilho and Fabiana Lascala Juliani and Rafaella Caroline de Lellis Moreira and Livia Dias Guerra and Fernanda Silva Santos and Daniela Morais de Holanda Padilha and Sandra Regina Branbilla and Vivian Naomi Horita and Davi Magalhães Leite Novaes and Lígia Macedo Antunes-Correa and Carmem Silvia Passos Lima and Maria Carolina Santos Mendes and José Barreto Campello Carvalheira},

doi = {10.3389/fnut.2025.1472634},

issn = {2296-861X},

year  = {2025},

date = {2025-03-14},

urldate = {2025-03-14},

journal = {Front. Nutr.},

volume = {12},

publisher = {Frontiers Media SA},

abstract = {<jats:sec><jats:title>Background</jats:title><jats:p>Patients with head and neck cancer (HNC) are at increased risk of malnutrition due to the presence of tumor and treatments. Body composition is a prognostic factor in these patients. However, the relationship between adipose tissue characteristics and survival in HNC is still unclear.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the associations of adiposity, the radiodensity of adipose tissue and muscularity with the prognosis of patients with locally advanced HNC undergoing to chemoradiotherapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This retrospective study included 132 patients diagnosed with locally advanced HNC. Body composition assessment was performed using computed tomography (CT) images at the level of the third cervical vertebra (C3). The total adipose tissue radiodensity (TATR), the total adipose tissue index (TATI) and skeletal muscle index (SMI) were evaluated. The primary outcome was overall survival (OS).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Patients in the highest TATI tertile had a lower risk of mortality when compared to those in the lowest tertile, HR: 0.56, 95% confidence Interval (CI): 0.32–0.96; <jats:italic>p</jats:italic> = 0.039. The highest TATR tertile was not associated with death. Patients with greater adiposity had a higher median survival compared to patients with medium and lower TATI (<jats:italic>p</jats:italic> = 0.0193). Individuals with lower TATI had lower energy intake than patients with higher TATI (<jats:italic>p</jats:italic> = 0.03). Additionally, patients with low muscularity had worse OS in the multivariable analysis (HR: 1.77, 95% CI: 1.01–3.07; <jats:italic>p</jats:italic> = 0.044).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In patients with locally advanced HNC, our findings underscore the significance of elevated adiposity, beyond maintained muscularity, as independent protective factors for overall survival. Our study highlights the critical importance of assessing body composition and initiating early nutritional interventions to improve the prognosis of these patients.</jats:p></jats:sec>},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Pereira2025b,

title = {Investigating the Antibacterial and Antitumoral Activities of New Copper(II) Complexes with Trifluoromethyluracil Isomers},

author = {Gabriele de Menezes Pereira and Julia Helena Bormio Nunes and Silmara Cristina Lazarini Frajácomo and Wilton Rogério Lustri and Fernando Rodrigues Goulart Bergamini and Josélia Cristina de Oliveira Moreira and Robson Pontes and Ana Lucia T. G. Ruiz and João Ernesto de Carvalho and Wdeson Pereira Barros and Pedro Paulo Corbi},

doi = {10.1002/slct.202405096},

issn = {2365-6549},

year  = {2025},

date = {2025-02-00},

urldate = {2025-02-00},

journal = {ChemistrySelect},

volume = {10},

number = {6},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title>

                  <jats:p>

                    New copper(II) complexes, derived from the isomers 5‐(trifluoromethyl)uracil (

                    <jats:bold>

                      L

                      <jats:sub>1</jats:sub>

                    </jats:bold>

                    ) and 6‐(trifluoromethyl)uracil (

                    <jats:bold>

                      L

                      <jats:sub>2</jats:sub>

                    </jats:bold>

                    ) with 2,2′‐bipyridine (

                    <jats:bold>Bpy</jats:bold>

                    ), [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] and [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy], were synthesized, characterized, and evaluated for their antibacterial and antitumoral properties. Chemical analyses suggest the molecular formula CuC

                    <jats:sub>20</jats:sub>

                    H

                    <jats:sub>12</jats:sub>

                    F

                    <jats:sub>6</jats:sub>

                    N

                    <jats:sub>6</jats:sub>

                    O

                    <jats:sub>4</jats:sub>

                    ·H

                    <jats:sub>2</jats:sub>

                    O for both complexes. Infrared spectroscopic analyses indicate that trifluoromethyluracil isomers coordinate to copper(II) by the oxygen atoms. Structural confirmation of the [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex was obtained by single crystal X‐ray diffraction, where two L

                    <jats:sub>2</jats:sub>

                    molecules coordinate to the copper(II) ion by both oxygen atoms from carbonyl groups. The complexes demonstrated antibacterial activity against Gram‐positive

                    <jats:italic>Staphylococcus aureus</jats:italic>

                    and

                    <jats:italic>Bacillus cereus</jats:italic>

                    , and Gram‐negative

                    <jats:italic>Pseudomonas aeruginosa</jats:italic>

                    and

                    <jats:italic>Escherichia coli</jats:italic>

                    strains. The [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex exhibited the most promising results against

                    <jats:italic>P. aeruginosa</jats:italic>

                    , with a minimum inhibitory concentration (MIC) value of 0.478 mmol L

                    <jats:sup>−1</jats:sup>

                    . The [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex demonstrated antiproliferative effects on U251 and MCF‐7 cells, with GI

                    <jats:sub>50</jats:sub>

                    values (concentration that inhibits 50% of cell growth) of 2.18 ± 1.17 and 16.00 ± 10.07 µmol·L

                    <jats:sup>−1</jats:sup>

                    , whereas the [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex inhibited the growth of FaDu and U251 cells (GI

                    <jats:sub>50</jats:sub>

                    values 4.70 ± 2.69 µmol·L

                    <jats:sup>−1</jats:sup>

                    and 9.06 ± 3.86 µmol·L

                    <jats:sup>−1</jats:sup>

                    , respectively). Neither the precursors nor the copper(II) complexes affected the structure of CT‐DNA at the evaluated concentrations, suggesting that DNA is not the main cellular target of the complexes.

                  </jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{deAraujoFernandes2025,

title = {[99mTc]Technetium and Rhenium Dithiocarbazate Complexes: Chemical Synthesis and Biological Assessment},

author = {André Gustavo de Araujo Fernandes and Alyne Eloise Lafratta and Carolina Portela Luz and Debora Levy and Daniele de Paula Faria and Carlos Alberto Buchpiguel and Ulrich Abram and Victor Marcelo Deflon and Fabio Luiz Navarro Marques},

doi = {10.3390/pharmaceutics17010100},

issn = {1999-4923},

year  = {2025},

date = {2025-01-00},

urldate = {2025-01-00},

journal = {Pharmaceutics},

volume = {17},

number = {1},

publisher = {MDPI AG},

abstract = {<jats:p>Background/Objectives: Dithiocarbazates (DTCs) and their metal complexes have been studied regarding their property as anticancer activities. In this work, using S-benzyl-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pirazol-1-carbodithionate (H2bdtc), we prepared [ReO(bdtc)(Hbdtc)] and [[99mTc]TcO(bdtc)(Hbdtc)] complexes for tumor uptake and animal biodistribution studies. Methods: Re complex was prepared by a reaction of H2bdtc and (NBu4)[ReOCl4], the final product was characterized by IR, 1H NMR, CHN, and MS-ESI. 99mTc complex was prepared by the reaction of H2bdtc and [[99mTc]TcO4− and analyzed by planar and HPLC radiochromatography, and the stability was evaluated against amino acids and plasma. Biodistribution was performed in C57B/6 mice with B16F10 and TM1M implanted tumor. Results: Re is asymmetric coordinated by two dithiocarbazate ligands, one with O,N,S chelation, and the other with N,S chelation; [[99mTc]TcO(bdtc)(Hbdtc)] was prepared with a radiochemical yield of around 93%. The radioactive complex is hydrophobic (LogP = 1.03), stable for 6 h in PBS and L-histidine solution; stable for 1 h in plasma, but unstable in the presence of L-cysteine. Ex vivo biodistribution demonstrated that the compound has a fast and persistent (until 2 h) uptake by the spleen (55.46%), and tumor B16F10 and TM1M uptake is lower than 1%. In vivo SPECT/CT imaging confirmed ex vivo biodistribution, except by heterogenous TM1M accumulation but not in the B16-F10 lineage. Conclusions: H2bdtc proved to be an interesting chelator for rhenium or [99mTc]technetium. The right spleen uptake opened the opportunity to deepen the study of the molecule in this tissue and justifies future studies to identify the reason of heterogenous uptake in TM1M tumor uptake.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Genaro2025,

title = {Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn’s disease patients},

author = {Livia Moreira Genaro and Juliana Carron and Marina Moreira de Castro and Ana Paula Menezes de Freitas Franceschini and Gustavo Jacob Lourenço and Cristiane Kibune Nagasako Vieira da Cruz and Glaucia Fernanda Soares Rupert Reis and Livia Bitencourt Pascoal and Juliana Delgado Campos Mello and Isabela Machado Pereira and Millene Leal Nascimento and Priscilla De Sene Portel Oliveira and Ligiana Pires Corona and Maria de Lourdes Setsuko Ayrizono and Carmen Silvia Passos Lima and Raquel Franco Leal},

doi = {10.1177/03946320251319379},

issn = {2058-7384},

year  = {2025},

date = {2025-01-00},

urldate = {2025-01-00},

journal = {Int J Immunopathol Pharmacol},

volume = {39},

publisher = {SAGE Publications},

abstract = {<jats:p> Crohn’s disease (CD) involves immune system interactions with intestinal tissue, driven by pro-inflammatory cytokines like Tumor Necrosis Factor (TNF-α). Adalimumab, targeting TNF-α, regulates associated inflammatory responses. Despite being humanized, it may induce immunogenic processes, affecting treatment effectiveness. Thus, monitoring serum adalimumab and anti-drug antibody (ADA) levels can optimize therapy. Understanding genetic factors influencing adalimumab response can enhance personalized treatment and improve patient quality of life. We aimed to quantify adalimumab serum levels, assess test interchangeability, detect ADA, examine immune complex formation, and investigate genetic phenotypes related to immunogenicity in CD patients. Seventy CD patients in the maintenance phase with adalimumab were classified into active (CDA) and remission (CDR) groups. Adalimumab concentration was determined via enzyme-linked immunosorbent assay (ELISA—Promonitor) and lateral flow assay (Quantum Blue), with assay interchangeability assessed statistically. ADA and immune complex formation were quantified using ELISA assays. DNA was genotyped for the genes ATG16L1, CD96, and CD155. No significant differences in adalimumab serum concentrations were observed between groups, regardless of the assay. However, a statistical difference between the tests indicated measurement disparity ( P = 0.003), with moderate agreement (Lin’s correlation of 0.247). ADA was detected in 4 of 27 of the patients with infratherapeutic levels, 3 in the CDA group and 1 in the CDR group. Analysis of immune complexes revealed significantly higher concentrations in the CDA group ( P = 0.0125). The genotypic evaluation revealed significant associations for the CD96 CC (wild-type) genotype with higher CRP levels, colonic involvement, and infratherapeutic levels of adalimumab. ATG16L1 CC genotype was associated with higher CDEIS and fecal calprotectin values, while the variant (TT) genotype had lower platelet counts. The effectiveness of treatment with adalimumab was not directly related to higher medication levels in this cohort. The disparity between tests indicates the need to use only one test in patient follow-up to ensure accuracy in therapeutic monitoring. Genotypic differences highlight the correlation between the wild genotype for CD96 and ATG16L1 with unfavorable laboratory and endoscopic response to adalimumab. Finally, the more significant levels of immune complexes in the CDA group indicate an association with a worse response to adalimumab. </jats:p>},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{deMenezesPereira2025,

title = {Antibacterial profile and antiproliferative activities over human tumor cells of new silver(I) complexes containing two distinct trifluoromethyl uracil isomers},

author = {Gabriele de Menezes Pereira and Julia H. Bormio Nunes and Vinicius Souza Macedo and Douglas Henrique Pereira and Kaio Eduardo Buglio and Daniele D. Affonso and Ana Lucia T.G. Ruiz and João Ernesto de Carvalho and Silmara Cristina L. Frajácomo and Wilton R. Lustri and Carmen Silvia Passos Lima and Fernando R.G. Bergamini and Alexandre Cuin and Norberto Masciocchi and Pedro Paulo Corbi},

doi = {10.1016/j.jinorgbio.2024.112752},

issn = {0162-0134},

year  = {2025},

date = {2025-01-00},

urldate = {2025-01-00},

journal = {Journal of Inorganic Biochemistry},

volume = {262},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Liveraro2025,

title = {Improving resectable gastric cancer prognosis prediction: A machine learning analysis combining clinical features and body composition radiomics},

author = {Gianni S.S. Liveraro and Maria E.S. Takahashi and Fabiana Lascala and Luiz R. Lopes and Nelson A. Andreollo and Maria C.S. Mendes and Jun Takahashi and José B.C. Carvalheira},

doi = {10.1016/j.imu.2024.101608},

issn = {2352-9148},

year  = {2025},

date = {2025-00-00},

urldate = {2025-00-00},

journal = {Informatics in Medicine Unlocked},

volume = {52},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{A.D'Oliveira2025,

title = {Silver-dichloroquinoline Complexes: Synthesis, Structure and Antitubercular Properties},

author = {Kaíque A. D'Oliveira and Nícolas Glanzmann and Adilson D. da Silva and Carlos E. T. Bruzeguini and Marcos A. Ribeiro and Christian S. C. Canales and Cesar A. Roque-Borda and Fernando R. Pavan and Pedro P. Corbi and Norberto Masciocchi and Alexandre Cuin},

doi = {10.21577/0103-5053.20250048},

issn = {1678-4790},

year  = {2025},

date = {2025-00-00},

urldate = {2025-00-00},

journal = {J. Braz. Chem. Soc.},

publisher = {Sociedade Brasileira de Quimica (SBQ)},

abstract = {<jats:p>Synthesis, characterization, and antitubercular activity of three silver(I) complexes

with 4,7-dichloroquinoline (C9H5Cl 2N, DCQ), 2,2’-bipyridine (C10H8N2, Bpy)

and triphenylphosphine (C18H15P, PPh3) are presented. Complex 1 was formulated as

[Ag(H2O)(DCQ)2(μ-ONO2)Ag(NO3)(DCQ)2], 1:2 M:L1 molar ratio, L1 = DCQ. Complexes 2

[Ag(NO3)(DCQ)(Bpy)] and 3 [Ag(NO3)(DCQ)(PPh3)]2 exhibit 1:1:1 M:L1:L2 molar ratio, where

L2 = Bpy or PPh3. All compounds were analytically, spectroscopically, and structurally

characterized. The crystal and molecular structures of complexes 1 and 3 were determined by

conventional single-crystal X-ray diffraction, while the crystal structure of 2 was elucidated using

laboratory powder diffraction method. Elemental analyses, conductometry, infrared (IR), Raman,

UV-Vis, and 1

H, 13C{1

H}, 31P{1

H}, {1

H-15N} heteronuclear multiple bond correlation (HMBC)

nuclear magnetic resonance (NMR) spectroscopies, along with 1

H NMR T1 relaxation time

measurements, corroborate the proposed formulas. Complex 3, in the solid state, was found to

contain significant residual solvents (CH3OH and CH3CN). Consequently, its desolvation process

was investigated using IR microscopy and X-ray powder diffraction. In vitro biological assays

against Mycobacterium tuberculosis H37Rv (ATCC 27294) were performed for all compounds.

Complexes 1 and 3 shown the lowest concentration of the antibiotic at which 90% of the isolates

are inhibited (MIC90) of 7 ± 1 and 14 ± 3 µg mL–1, suggesting their potential as antimycobacterial

agents, in contrast, assays indicate lower activity for compound 2 against the evaluated strains.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{P.dosSantos2025,

title = {High Selective N-Acylhydrazones Silver(I) Complexes against Tuberculosis},

author = {Paulo Victor P. dos Santos and Nícolas Glanzmann and Adilson D. da Silva and Fernando R. Pavan and Christian S. C. Canales and Cesar A. Roque‑Borda and Pedro P. Corbi and Douglas H. Pereira and Kaíque A. D'Oliveira and Alexandre Cuin},

doi = {10.21577/0103-5053.20250093},

issn = {1678-4790},

year  = {2025},

date = {2025-00-00},

urldate = {2025-00-00},

journal = {J. Braz. Chem. Soc.},

publisher = {Sociedade Brasileira de Quimica (SBQ)},

abstract = {<jats:p>In the present work, synthesis, characterization, and biological assays of seven N-acylhydrazones

derivatives of isoniazid and their corresponding silver(I) complexes are described. The compounds

were characterized by elemental analysis, infrared (IR) and 1 H, 13C and 1

H-15N nuclear magnetic

resonance (NMR) spectroscopic measurements, and molar conductivity over 48 h assays. Density

functional theory (DFT) studies also were employed in order to structural elucidation of the

seven silver(I) complexes. All the synthesized silver complexes have shown minimum inhibitory

concentration (MIC90) values against Mycobacterium tuberculosis - MtbH37Rv (ATCC 27294)

lower than 7.421 mg L–1. The AgIZBEN complex showed the most promising anti-tuberculosis

action, with MIC90 of 0.956 mg L–1 and selectivity index (SI) = 29.3 while the AgIZpAN showed

SI higher than 460 and MIC90 of 1.077 mg L–1. The free acylhydrazones derivatives also showed

SI higher than 20.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Rezende2024,

title = {Coordination Compounds as Antivirals against Neglected Tropical Diseases},

author = {Wallace S. Rezende and Antonio Marçal Neto and Juliano J. Corbi and Pedro P. Corbi and Raphael E. F. de Paiva and Fernando R. G. Bergamini},

doi = {10.1002/cmdc.202400799},

issn = {1860-7187},

year  = {2024},

date = {2024-12-09},

urldate = {2024-12-09},

journal = {ChemMedChem},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:p>Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen‐related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate‐to‐cold environments. The slow‐paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS‐CoV‐2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod‐borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Machado2024,

title = {A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel},

author = {Raiane Aparecida dos Santos Machado and Raoni Pais Siqueira and Fernanda Cardoso da Silva and André Carlos Pereira de Matos and Dayanne Silva Borges and Gislaine Gonçalves Rocha and Thais Cristina Prado de Souza and Rafael Aparecido Carvalho Souza and Clayton Rodrigues de Oliveira and Antônio G. Ferreira and Pedro Ivo da Silva Maia and Victor Marcelo Deflon and Carolina Gonçalves Oliveira and Thaise Gonçalves Araújo},

doi = {10.3390/pharmaceutics16121610},

issn = {1999-4923},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Pharmaceutics},

volume = {16},

number = {12},

publisher = {MDPI AG},

abstract = {<jats:p>Background/Objectives: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of breast cancer (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity to conventional drugs. Zinc is an important trace element for homeostasis, and its Schiff base metal complexes have shown promise in treating advanced tumors. In this study, four new heteroleptic Zn(II) complexes (1–4) with Schiff bases were synthesized, characterized, and evaluated for their activity in BC cells. Methods: Compounds were synthesized, characterized, and their crystal structures were determined. Biological activity was assessed using MTT, clonogenic, scratch wound healing, caspase 3 and 8 activity, qPCR, and chemosensitization assays. Results: The complexes exhibited cytotoxicity against MCF-7 (luminal BC), MDA-MB-453 (HER2-positive BC), and MDA-MB-231 (TNBC) cell lines, with IC50 values ranging from 0.01 to 20 µM. Complex 4 showed reduced cytotoxicity toward non-tumor cell lines. This, complexation with Zn(II) increased the cytotoxicity of the ligands, a trend not observed for complexes 1–3. Due to its favorable profile, complex 4 was selected for further assays, in which it inhibited colony formation and the cell migration of TNBC cells in a dose-dependent manner. Furthermore, this compound induced cell death independently of caspases, decreasing the activity of caspase 8. Interestingly, complex 4 sensitized TBNC cells to doxorubicin and paclitaxel, possibly modulating the epithelial–mesenchymal transition mechanism, as evidenced by increased CDH1 expression. Conclusions: Results suggest the potential of complex 4 in sensitizing aggressive BC cells to chemotherapy, proving to be a promising alternative in cases of therapeutic failure.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Carron2024b,

title = {The impact of ERP29 on the progression of pharyngeal squamous cell carcinoma},

author = {Juliana Carron and Lilian de Oliveira Coser and Carmen Silvia Passos Lima and Gustavo Jacob Lourenço},

doi = {10.1038/s41598-024-76210-6},

issn = {2045-2322},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Sci Rep},

volume = {14},

number = {1},

publisher = {Springer Science and Business Media LLC},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendonça2024d,

title = {Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents},

author = {Fernanda Ferreira Mendonça and Danielle Vieira Sobral and Ana Claudia Ranucci Durante and Ana Cláudia Camargo Miranda and Jorge Mejia and Daniele de Paula Faria and Fabio Luiz Navarro Marques and Marycel Figols de Barboza and Leonardo Lima Fuscaldi and Luciana Malavolta},

doi = {10.1007/s00726-023-03379-x},

issn = {1438-2199},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Amino Acids},

volume = {56},

number = {1},

publisher = {Springer Science and Business Media LLC},

abstract = {<jats:title>Abstract</jats:title><jats:p>Breast cancer remains a pressing public health issue primarily affecting women. Recent research has spotlighted bioactive peptides derived from laminin-111, implicated in breast tumor development. Remarkably, the sequences IKVAV, YIGSR, and KAFDITYVRLKF from the α1, β1, and γ1 chains, respectively, have garnered significant attention. This study aims to assess the potential of these radiolabeled peptides as targeting agents for breast cancer. The three peptides were synthesized using the Fmoc strategy, purified via reversed-phase high-performance liquid chromatography (RP-HPLC), and characterized through mass spectrometry. Iodine-131 (<jats:sup>131</jats:sup>I) radiolabeling was performed using the chloramine T method, exhibiting high radiochemical yield and stability for [<jats:sup>131</jats:sup>I]I-YIKVAV and [<jats:sup>131</jats:sup>I]I-YIGSR. Conversely, [<jats:sup>131</jats:sup>I]I-KAFDITYVRLKF demonstrated low radiochemical yield and stability and was excluded from the biological studies. The lipophilicity of the compounds ranged from − 2.12 to − 1.10. Serum protein binding assay for [<jats:sup>131</jats:sup>I]I-YIKVAV and [<jats:sup>131</jats:sup>I]I-YIGSR reached ≅ 48% and ≅ 25%, respectively. Affinity for breast cancer cells was evaluated using MDA-MB-231 and MCF-7 tumor cell lines, indicating the affinity of the radiopeptides with these tumor cells. Ex vivo biodistribution profiles of the radiopeptides were assessed in the MDA-MB-231 breast tumor animal model, revealing tumor tissue accumulation, supported by a high tumor-to-contralateral muscle ratio and autoradiography. These results signify the effective penetration of YIKVAV and YIGSR into tumor tissue. Therefore, the synthesized α1 and β1 peptide fragments exhibit favorable characteristics as potential breast cancer-targeting agents, promising future exploration as radiopharmaceuticals for breast cancer.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Padilha2024,

title = {Subcutaneous adipose tissue radiodensity: An emerging risk factor for severe COVID-19},

author = {Daniela M.H. Padilha and Maria C.S. Mendes and Maria E.S. Takahashi and Fabiana Lascala and Marina N. Silveira and Lara Pozzuto and Larissa A.O. Carrilho and Lívia D. Guerra and Rafaella C.L. Moreira and Sandra R. Branbilla and Celso Darío Ramos and José B.C. Carvalheira},

doi = {10.1016/j.nut.2024.112561},

issn = {0899-9007},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Nutrition},

volume = {128},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}