Lista completa de Publicações

@article{Rezende2024,

title = {Coordination Compounds as Antivirals against Neglected Tropical Diseases},

author = {Wallace S. Rezende and Antonio Marçal Neto and Juliano J. Corbi and Pedro P. Corbi and Raphael E. F. de Paiva and Fernando R. G. Bergamini},

doi = {10.1002/cmdc.202400799},

issn = {1860-7187},

year  = {2024},

date = {2024-12-09},

urldate = {2024-12-09},

journal = {ChemMedChem},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:p>Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen‐related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate‐to‐cold environments. The slow‐paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS‐CoV‐2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod‐borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Lima2024b,

title = {Theranostics Nuclear Medicine in Prostate Cancer},

author = {Helena Lima and Marina Etchebehere and Mateos Bogoni and Caroline Torricelli and Ellen Nogueira-Lima and Victor M. Deflon and Mariana Lima and Elba Etchebehere},

doi = {10.3390/ph17111483},

issn = {1424-8247},

year  = {2024},

date = {2024-11-00},

urldate = {2024-11-00},

journal = {Pharmaceuticals},

volume = {17},

number = {11},

publisher = {MDPI AG},

abstract = {<jats:p>Theranostic Nuclear Medicine is based on the idea of combining the same molecule (or drug) with different radioisotopes for both diagnosis and treatment, a concept that emerged in the early 1940s with the use of radioactive iodine for thyroid diseases. Theranostic Nuclear Medicine has since expanded to diseases of higher incidence, such as prostate cancer, with several imaging methods used to assess the extent of the disease and the corresponding radiopharmaceuticals used for treatment. For example, by detecting osteoblastic metastases by bone scintigraphy, corresponding radiopharmaceuticals with therapeutic properties can be administered to eliminate or reduce pain associated with metastases and/or determine overall survival gain. The purpose of this review is to discuss the role of Theranostic Nuclear Medicine in prostate cancer, addressing the main diagnostic imaging studies with their corresponding treatments in the Theranostic model.</jats:p>},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39366100,

title = {Antibacterial profile and antiproliferative activities over human tumor cells of new silver(I) complexes containing two distinct trifluoromethyl uracil isomers},

author = {Gabriele de Menezes Pereira and Julia H Bormio Nunes and Vinicius Souza Macedo and Douglas Henrique Pereira and Kaio Eduardo Buglio and Daniele D Affonso and Ana Lucia T G Ruiz and João Ernesto de Carvalho and Silmara Cristina L Frajácomo and Wilton R Lustri and Carmen Silvia Passos Lima and Fernando R G Bergamini and Alexandre Cuin and Norberto Masciocchi and Pedro Paulo Corbi},

doi = {10.1016/j.jinorgbio.2024.112752},

issn = {1873-3344},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-01},

journal = {J Inorg Biochem},

volume = {262},

pages = {112752},

abstract = {New silver(I) complexes of 5-(trifluoromethyl)uracil (5TFMU) and 6-(trifluoromethyl)uracil (6TFMU) isomers were synthesized, characterized, and evaluated as antibacterial and antiproliferative agents. Based on elemental and thermogravimetric analyses, the Ag-5TFMU and Ag-6TFMU species are formulated as AgCHFNO and AgCHFNO, respectively. Infrared and C solid-state nuclear magnetic resonance spectroscopies suggest coordination of the trifluoromethyluracil isomers to silver by both nitrogen and oxygen atoms. Confirmation of their structure and connectivity was achieved, in the absence of single crystals of suitable quality, by state-of-the-art structural powder diffraction methods. In Ag-5TFMU, the organic ligand is tridentate and two distinct metal coordination environments are found (linear AgN as well as C AgO geometries), whereas Ag-6TFMU contains a complex polymeric structure with tetradentate dianionic 6TFMU moieties and five distinct AgX (X = N, O) fragments, further stabilized by ancillary (longer) AgO contacts. These species presented modest activity over Gram-positive and Gram-negative bacterial strains, whereas Ag-6TFMU was active over a set of tumor cells, with the best activity over prostate (PC-3) and kidney cell lines and selectivity indices of 4.6 and 1.3, respectively. On the other hand, Ag-5TFMU was active over all considered tumor cells except MCF-7 (breast cancer). The best activity was found for PC-3 cells, but no selectivity was observed. The Ag-5TFMU and Ag-6TFMU species also reduced the proliferation of tongue squamous cell carcinoma cell lines SCC - 4 and SCC-15. Preliminary biophysical assays by circular dichroism suggest that the Ag-5TFMU complex interacts with DNA by intercalation, an effect not seen in Ag-6TFMU.},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{RodriguesToledo2024,

title = {EGFR- and Integrin αVβ3-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics},

author = {Cibele Rodrigues Toledo and Ahmed A. Tantawy and Leonardo Lima Fuscaldi and Luciana Malavolta and Carolina de Aguiar Ferreira},

doi = {10.3390/ijms25158553},

issn = {1422-0067},

year  = {2024},

date = {2024-08-00},

urldate = {2024-08-00},

journal = {IJMS},

volume = {25},

number = {15},

publisher = {MDPI AG},

abstract = {<jats:p>The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These agents exploit the overexpression or mutations of specific receptors, such as the Epidermal Growth Factor receptor (EGFR) and αVβ3 integrin, which are pivotal in tumor growth, angiogenesis, and metastasis. Despite the extensive research into and promising outcomes associated with antibody-based therapies, peptides offer a compelling alternative due to their smaller size, ease of modification, and rapid bioavailability, factors which potentially enhance tumor penetration and reduce systemic toxicity. However, the application of peptides in clinical settings has challenges. Their lower binding affinity and rapid clearance from the bloodstream compared to antibodies often limit their therapeutic efficacy and diagnostic accuracy. This overview sets the stage for a comprehensive review of the current research landscape as it relates to EGFR- and integrin αVβ3-targeting peptides. We aim to delve into their synthesis, radiolabeling techniques, and preclinical and clinical evaluations, highlighting their potential and limitations in cancer theranostics. This review not only synthesizes the extant literature to outline the advancements in peptide-based agents targeting EGFR and integrin αVβ3 but also identifies critical gaps that could inform future research directions. By addressing these gaps, we contribute to the broader discourse on enhancing the diagnostic precision and therapeutic outcomes of cancer treatments.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Candido2024,

title = {Crystal Structure and Anti-Proliferative and Mutagenic Evaluation of the Palladium(II) Complex of Deoxyalliin},

author = {Tuany Zambroti Candido and Mariana Mazzo Quintanilha and Bianca Alves Schimitd and Déborah de Alencar Simoni and Douglas Hideki Nakahata and Raphael Enoque Ferraz de Paiva and Igor Henrique Cerqueira and Flávia Aparecida Resende and João Ernesto Carvalho and Ana Lucia Tasca Gois Ruiz and Carmen Silvia Passos Lima and Pedro Paulo Corbi},

doi = {10.3390/inorganics12070194},

issn = {2304-6740},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {Inorganics},

volume = {12},

number = {7},

publisher = {MDPI AG},

abstract = {<jats:p>Platinum(II) and palladium(II) complexes have been investigated as potential anticancer drugs since the serendipitous discovery of the antineoplastic activities of cisplatin in the 1960s. Skin cancer is considered the most common malignant neoplasm that affects humans, and melanoma is the most lethal type of skin cancer. Surgical excision is the main form of treatment, which also may include radiotherapy, systemic chemotherapy, and immunotherapy. In this work, new insights concerning the structural characterization and in vitro anti-proliferative activity of the palladium(II) complex with the amino acid deoxyalliin (Pd-sac) against a panel of thirteen human tumor cells, with emphasis on skin cancer cell lines, are presented. The composition of the complex was confirmed by elemental analysis as [Pd(C6H10NO2S)2]. The structure of the complex was elucidated for the first time by a single-crystal X-ray diffraction technique. Each deoxyalliin molecule coordinates in a bidentate N,S-mode to palladium(II) in a trans-configuration analogous to the platinum(II) deoxyalliin complex early reported. As the main result, the Pd-sac complex showed a selective anti-proliferative activity against melanoma (UACC-62, TGI = 63.5 µM), while both deoxyalliin and K2PdCl4 were inactive against all cell lines. Moreover, Pd-sac did not affect the proliferation of non-tumorigenic keratinocytes (HaCaT, TGI > 586 µM) and was non-mutagenic in the Ames assay. The results open new perspectives for in vivo studies concerning the application of the Pd-sac complex in the treatment of melanoma.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Almeida2024,

title = {Radioligand Therapy in Lymphoma},

author = {Ludmila Santiago Almeida and Roberto C. Delgado Bolton and Victor Cabral Heringer and Samuel de Souza Medina and Elba Etchebehere},

doi = {10.1016/j.cpet.2024.05.003},

issn = {1556-8598},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {PET Clinics},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Carron2024,

title = {INFLUENCE OF A CONVENTIONAL CHELATOR-MODIFIED ANTI-INTEGRIN PEPTIDE ON PROLIFERATION AND MIGRATION OF HEAD AND NECK CANCER CELLS},

author = {Juliana Carron and Daniele Daiane Affonso and Suelen Aparecida Ribeiro Souza and Ana Maria Castro Ferreira and João Ernesto Carvalho and Ana Lucia Tasca Gois Ruiz and Gabriella Fraiji Melo and Flávio Lopes Alves and Leonardo Lima Fuscaldi and Luciana Malavolta and Carmen Silvia Passos Lima},

doi = {10.1016/j.htct.2024.04.081},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Affonso2024,

title = {EVALUATION IN VITRO OF THE GOLD(I) COMPLEX WITH TRIPHENYLPHOSPHINE AND 4-DIMETHYLAAMINEPYRIDINE AS LIGANDS IN SKIN CANCER},

author = {Daniele Daiane Affonso and Tuany Zambroti Candido and João Ernesto de Carvalho and Pedro Paulo Corbi and Camilla Abbehausen and Ana Lucia Tasca Gois Ruiz and Carmen Silvia Passos Lima},

doi = {10.1016/j.htct.2024.04.083},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S21--S22},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Lima2024,

title = {PRELIMINARY ANTI-PROLIFERATIVE ACTIVITIES OF A PALLADIUM(II) COMPLEX OVER SQUAMOUS CELL CARCINOMA OF TONGUE},

author = {Carmen Silvia Passos Lima and Tuany Zambroti Candido and João Ernesto de Carvalho and Ana Lucia Tasca Gois Ruiz and Pedro Paulo Corbi},

doi = {10.1016/j.htct.2024.04.075},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S16--S17},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Rodrigues2024,

title = {ASSESSMENT OF IN VITRO STUDIES OF [131I]I-LABELED DEDEYFELV PEPTIDE AS PROSPECTIVE BIOMARKER FOR GLIOBLASTOMA},

author = {Fernanda Paiva Augusto Rodrigues and Júlia Calviello Giordano and Danielle Vieira Sobral and Ana Cláudia Camargo Miranda and Leonardo Lima Fuscaldi and Marycel Figols de Barboza and João Luiz Vitorino Araújo and Luciana Malavolta},

doi = {10.1016/j.htct.2024.04.063},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S9--S10},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendes2024,

title = {EVALUATION OF POTENTIAL PEPTIDE INHIBITORS THAT INTERACT WITH THE EGF RECEPTOR. RELEVANCE TO GLIOBLASTOMA},

author = {Lorena Marinelli Mendes and Danielle Vieira Sobral and Érica Victória dos Santos and Leonardo Lima Fuscaldi and Luciana Malavolta},

doi = {10.1016/j.htct.2024.04.061},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendonça2024,

title = {ASSESSMENT OF IN VITRO INTERACTIONS BETWEEN RADIOLABELED EGFR-TARGETING PEPTIDE INHIBITORS AND GLIOBLASTOMA CELLS},

author = {Fernanda Ferreira Mendonça and Alice Santos de Miranda and Henrique Massao Achidate Makino and Lorena Marinelli Mendes and Danielle Vieira Sobral and Marycel Figols de Barboza and Luciana Malavolta and Leonardo Lima Fuscaldi},

doi = {10.1016/j.htct.2024.04.065},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S10--S11},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendonça2024b,

title = {INVESTIGATION OF THE IN VITRO ASSESSMENT OF 99MTC-LABELED LAMININ-111 PEPTIDES AS PROSPECTIVE BIOMARKERS FOR BREAST CANCER},

author = {Fernanda Ferreira Mendonça and Maria Emilia Tejeria Perez and Paula Decuadra and Maia Zeni and Ana Rey and Leonardo Lima Fuscaldi and Luciana Malavolta},

doi = {10.1016/j.htct.2024.04.062},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S8--S9},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendonça2024c,

title = {SYNTHESIS AND EVALUATION OF BIOACTIVE PEPTIDES FROM LAMININ-111 IN TRIPLE-NEGATIVE BREAST CANCER CELLS},

author = {Fernanda Ferreira Mendonça and Júlia Torquato Vieira and Danielle Vieira Sobral and Érica Victória dos Santos and Leonardo Lima Fuscaldi and Luciana Malavolta},

doi = {10.1016/j.htct.2024.04.064},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendanha2024,

title = {COMPARISON OF PET/CT IMAGES WITH 18F-FDG AND 18F-PSMA-1007 IN METASTATIC ACRAL MELANOMA: A CASE REPORT},

author = {Diego Machado Mendanha and Natalia Tobar and Ligia Traldi Macedo and Allan Oliveira Santos and Mariana Cunha Lopes de Lima and Elba Cristina Sá de Camargo Etchebehere and Carmen Silvia Passos Lima},

doi = {10.1016/j.htct.2024.04.102},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Sousa2024,

title = {COMPARISON OF 18 F-FDG AND 18 F-PSMA-1007 PET/CT IN ADVANCED LOCOREGIONAL SQUAMOUS CELL CARCINOMA OF HEAD AND NECK: PRELIMINARY RESULTS},

author = {Hadila Da Silva Veras Sousa and Kaique Moraes do Amaral and Najua Abou Arab and Simone Kuba and Lígia Traldi Macedo and Bárbara Juarez Amorim and Celso Dario Ramos and Carmen Silvia Passos Lima},

doi = {10.1016/j.htct.2024.04.084},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S22--S23},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Silva2024,

title = {COMPARISON OF PET/CT IMAGES WITH 18F-FDG AND 18F-PSMA-1007 IN MUSCULOSKELETAL TUMORS TO EVALUATE THE POTENTIAL OF THERANOSTICS APPROACH},

author = {Mayara Branco E. Silva and Natalia Tobar and Allan de Oliveira Santos and Gardenia De Oliveira Barbosa and Carlos Eduardo Hideo Hanasilo and Mariana Da Cunha Lopes de Lima and Mauricio Etchebehere and Elba Cristina Sa de Camargo Etchebehere},

doi = {10.1016/j.htct.2024.04.089},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S25--S26},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Sousa2024b,

title = {COMPARISON OF PET/CT IMAGES WITH 18 F-FDG AND 18 F-PSMA-1007 IN RELAPSED ADENOID CYSTIC CARCINOMA},

author = {Hadila Da Silva Veras Sousa and Natália Tobar and Lígia Traldi Macedo and Simone Kuba and Allan de Oliveira Santos and Bárbara Juarez Amorim and Carmen Silvia Passos Lima and Elba Cristina Sá de Camargo Etchebehere},

doi = {10.1016/j.htct.2024.04.082},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{doNascimento2024,

title = {18F-FLUORIDE PET/CT vs 18F-PSMA-1007 TO DETECT BONE METASTASES IN PROSTATE CANCER – A HEAD-TO-HEAD PROSPECTIVE COMPARISON},

author = {Beatriz Birelli do Nascimento and Allan Santos and Natalia Tobar and Fabiana Mori and Mariana Camacho and Mariana Lima and Edna Brunetto and Sergio Brunetto and Anelise Ruzzarin and Juliana Ciampi and Marina Silveira and Gardenia Oliveira Barbosa and Wagner Matheus and Ubirajara Ferreira and Elba Etchebehere},

doi = {10.1016/j.htct.2024.04.088},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S24--S25},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Heringer2024,

title = {177LU-PSMA IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER: PRELIMINARY ANALYSIS OF A BRAZILIAN MULTICENTRIC STUDY},

author = {Victor Cabral Costa Ribeiro Heringer and Felipe P.G. Ribeiro and Diogo Bastos and Camila Mosci and Dalton A. Anjos and Paulo Almeida Filho and Gustavo Gomes and Filipe Villela-Pedras and Fabio Ribeiro and Julio Correia and José F. Marin and Carlos Buchpiguel and Elba C.S.C. Etchebehere},

doi = {10.1016/j.htct.2024.04.071},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}