Lista completa de Publicações

@article{deLacerda2026b,

title = {A new palladium(II) complex containing ethylenediamine and 2-thioxo-4-thiazolidinone exhibits high activity against resistant Campylobacter jejuni strains},

author = {Meiry Leandra de Lacerda and Letícia Roberta Martins Costa and Dayanne Maria da Silva Coimbra and Gabriele de Menezes Pereira and Clara Maria Faria Silva and Pedro Paulo Corbi and Daise Aparecida Rossi and Robson José de Oliveira Júnior and Roberta Torres de Melo and Wendell Guerra},

doi = {10.1016/j.ica.2025.122913},

issn = {0020-1693},

year  = {2026},

date = {2026-01-00},

urldate = {2026-01-00},

journal = {Inorganica Chimica Acta},

volume = {589},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Mastrobuono-Cordeiro2026,

title = {Synthesis, structural characterization and biological evaluation of silver(I) complexes with 2-thiouracil and 2,4-dithiouracil},

author = {Francisco Mastrobuono-Cordeiro and Julia H. Bormio Nunes and Gabriele de M. Pereira and Douglas H. Nakahata and Silmara C.L. Frajácomo and Wilton R. Lustri and João Ernesto de Carvalho and Douglas H. Pereira and Ana Lúcia T.G. Ruiz and Raphael E.F. de Paiva and Pedro P. Corbi},

doi = {10.1016/j.ica.2025.122971},

issn = {0020-1693},

year  = {2026},

date = {2026-01-00},

urldate = {2026-01-00},

journal = {Inorganica Chimica Acta},

volume = {590},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Coelho2025,

title = {Exploring biological properties of sulfa-based copper(II) complexes: in vitro genotoxicity, cytotoxicity (2D and 3D) and mechanistic insights},

author = {Maria Paula M. Coelho and Gabriele de Menezes Pereira and Pedro Paulo Corbi and Douglas H. Nakahata and Valentina Gandin and Chiara Donati and Juliana F. Vecina and Ana Lucia T. G. Ruiz},

doi = {10.1007/s10534-025-00719-0},

issn = {1572-8773},

year  = {2025},

date = {2025-10-00},

urldate = {2025-10-00},

journal = {Biometals},

volume = {38},

number = {5},

pages = {1551--1567},

publisher = {Springer Science and Business Media LLC},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Nakahata2025,

title = {Pd(II) complexes of 4-(2-aminoethyl)benzenesulfonamide Schiff bases: Structure, DNA binding and antiproliferative activity},

author = {Douglas H. Nakahata and Gabriele de M. Pereira and Marcos A. Ribeiro and Igor S. Oliveira and Josélia C. de Oliveira Moreira and Robson Pontes and João E. de Carvalho and Ana Lucia T.G. Ruiz and Nicholas P. Farrell and Pedro P. Corbi},

doi = {10.1016/j.ica.2025.122659},

issn = {0020-1693},

year  = {2025},

date = {2025-06-00},

urldate = {2025-06-00},

journal = {Inorganica Chimica Acta},

volume = {581},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Pereira2025,

title = {Evaluation of quality parameters, physicochemical and bioactive properties of licuri oil (Syagrus coronata)},

author = {Gabriel Sthefano Lourenço Pereira and Patrícia Tonon de Souza and Grace Kelly Mizuno Flozino and Rafael Fernandes Almeida and Dhayna Oliveira Sobral and Marcelo Antonio Morgano and Wilton Rogério Lustri and Silmara Cristina Lazarini and Pedro Paulo Corbi and Antonio José de Almeida Meirelles and Guilherme José Maximo and Eduardo Augusto Caldas Batista and Klicia Araujo Sampaio},

doi = {10.1016/j.foodres.2025.116157},

issn = {0963-9969},

year  = {2025},

date = {2025-05-00},

urldate = {2025-05-00},

journal = {Food Research International},

volume = {208},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Pereira2025b,

title = {Investigating the Antibacterial and Antitumoral Activities of New Copper(II) Complexes with Trifluoromethyluracil Isomers},

author = {Gabriele de Menezes Pereira and Julia Helena Bormio Nunes and Silmara Cristina Lazarini Frajácomo and Wilton Rogério Lustri and Fernando Rodrigues Goulart Bergamini and Josélia Cristina de Oliveira Moreira and Robson Pontes and Ana Lucia T. G. Ruiz and João Ernesto de Carvalho and Wdeson Pereira Barros and Pedro Paulo Corbi},

doi = {10.1002/slct.202405096},

issn = {2365-6549},

year  = {2025},

date = {2025-02-00},

urldate = {2025-02-00},

journal = {ChemistrySelect},

volume = {10},

number = {6},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title>

                  <jats:p>

                    New copper(II) complexes, derived from the isomers 5‐(trifluoromethyl)uracil (

                    <jats:bold>

                      L

                      <jats:sub>1</jats:sub>

                    </jats:bold>

                    ) and 6‐(trifluoromethyl)uracil (

                    <jats:bold>

                      L

                      <jats:sub>2</jats:sub>

                    </jats:bold>

                    ) with 2,2′‐bipyridine (

                    <jats:bold>Bpy</jats:bold>

                    ), [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] and [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy], were synthesized, characterized, and evaluated for their antibacterial and antitumoral properties. Chemical analyses suggest the molecular formula CuC

                    <jats:sub>20</jats:sub>

                    H

                    <jats:sub>12</jats:sub>

                    F

                    <jats:sub>6</jats:sub>

                    N

                    <jats:sub>6</jats:sub>

                    O

                    <jats:sub>4</jats:sub>

                    ·H

                    <jats:sub>2</jats:sub>

                    O for both complexes. Infrared spectroscopic analyses indicate that trifluoromethyluracil isomers coordinate to copper(II) by the oxygen atoms. Structural confirmation of the [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex was obtained by single crystal X‐ray diffraction, where two L

                    <jats:sub>2</jats:sub>

                    molecules coordinate to the copper(II) ion by both oxygen atoms from carbonyl groups. The complexes demonstrated antibacterial activity against Gram‐positive

                    <jats:italic>Staphylococcus aureus</jats:italic>

                    and

                    <jats:italic>Bacillus cereus</jats:italic>

                    , and Gram‐negative

                    <jats:italic>Pseudomonas aeruginosa</jats:italic>

                    and

                    <jats:italic>Escherichia coli</jats:italic>

                    strains. The [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex exhibited the most promising results against

                    <jats:italic>P. aeruginosa</jats:italic>

                    , with a minimum inhibitory concentration (MIC) value of 0.478 mmol L

                    <jats:sup>−1</jats:sup>

                    . The [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>1</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex demonstrated antiproliferative effects on U251 and MCF‐7 cells, with GI

                    <jats:sub>50</jats:sub>

                    values (concentration that inhibits 50% of cell growth) of 2.18 ± 1.17 and 16.00 ± 10.07 µmol·L

                    <jats:sup>−1</jats:sup>

                    , whereas the [Cu(H

                    <jats:sub>2</jats:sub>

                    O)(L

                    <jats:sub>2</jats:sub>

                    )

                    <jats:sub>2</jats:sub>

                    Bpy] complex inhibited the growth of FaDu and U251 cells (GI

                    <jats:sub>50</jats:sub>

                    values 4.70 ± 2.69 µmol·L

                    <jats:sup>−1</jats:sup>

                    and 9.06 ± 3.86 µmol·L

                    <jats:sup>−1</jats:sup>

                    , respectively). Neither the precursors nor the copper(II) complexes affected the structure of CT‐DNA at the evaluated concentrations, suggesting that DNA is not the main cellular target of the complexes.

                  </jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{deAraujoFernandes2025,

title = {[99mTc]Technetium and Rhenium Dithiocarbazate Complexes: Chemical Synthesis and Biological Assessment},

author = {André Gustavo de Araujo Fernandes and Alyne Eloise Lafratta and Carolina Portela Luz and Debora Levy and Daniele de Paula Faria and Carlos Alberto Buchpiguel and Ulrich Abram and Victor Marcelo Deflon and Fabio Luiz Navarro Marques},

doi = {10.3390/pharmaceutics17010100},

issn = {1999-4923},

year  = {2025},

date = {2025-01-00},

urldate = {2025-01-00},

journal = {Pharmaceutics},

volume = {17},

number = {1},

publisher = {MDPI AG},

abstract = {<jats:p>Background/Objectives: Dithiocarbazates (DTCs) and their metal complexes have been studied regarding their property as anticancer activities. In this work, using S-benzyl-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pirazol-1-carbodithionate (H2bdtc), we prepared [ReO(bdtc)(Hbdtc)] and [[99mTc]TcO(bdtc)(Hbdtc)] complexes for tumor uptake and animal biodistribution studies. Methods: Re complex was prepared by a reaction of H2bdtc and (NBu4)[ReOCl4], the final product was characterized by IR, 1H NMR, CHN, and MS-ESI. 99mTc complex was prepared by the reaction of H2bdtc and [[99mTc]TcO4− and analyzed by planar and HPLC radiochromatography, and the stability was evaluated against amino acids and plasma. Biodistribution was performed in C57B/6 mice with B16F10 and TM1M implanted tumor. Results: Re is asymmetric coordinated by two dithiocarbazate ligands, one with O,N,S chelation, and the other with N,S chelation; [[99mTc]TcO(bdtc)(Hbdtc)] was prepared with a radiochemical yield of around 93%. The radioactive complex is hydrophobic (LogP = 1.03), stable for 6 h in PBS and L-histidine solution; stable for 1 h in plasma, but unstable in the presence of L-cysteine. Ex vivo biodistribution demonstrated that the compound has a fast and persistent (until 2 h) uptake by the spleen (55.46%), and tumor B16F10 and TM1M uptake is lower than 1%. In vivo SPECT/CT imaging confirmed ex vivo biodistribution, except by heterogenous TM1M accumulation but not in the B16-F10 lineage. Conclusions: H2bdtc proved to be an interesting chelator for rhenium or [99mTc]technetium. The right spleen uptake opened the opportunity to deepen the study of the molecule in this tissue and justifies future studies to identify the reason of heterogenous uptake in TM1M tumor uptake.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{P.dosSantos2025,

title = {High Selective N-Acylhydrazones Silver(I) Complexes against Tuberculosis},

author = {Paulo Victor P. dos Santos and Nícolas Glanzmann and Adilson D. da Silva and Fernando R. Pavan and Christian S. C. Canales and Cesar A. Roque‑Borda and Pedro P. Corbi and Douglas H. Pereira and Kaíque A. D'Oliveira and Alexandre Cuin},

doi = {10.21577/0103-5053.20250093},

issn = {1678-4790},

year  = {2025},

date = {2025-00-00},

urldate = {2025-00-00},

journal = {J. Braz. Chem. Soc.},

publisher = {Sociedade Brasileira de Quimica (SBQ)},

abstract = {<jats:p>In the present work, synthesis, characterization, and biological assays of seven N-acylhydrazones

derivatives of isoniazid and their corresponding silver(I) complexes are described. The compounds

were characterized by elemental analysis, infrared (IR) and 1 H, 13C and 1

H-15N nuclear magnetic

resonance (NMR) spectroscopic measurements, and molar conductivity over 48 h assays. Density

functional theory (DFT) studies also were employed in order to structural elucidation of the

seven silver(I) complexes. All the synthesized silver complexes have shown minimum inhibitory

concentration (MIC90) values against Mycobacterium tuberculosis - MtbH37Rv (ATCC 27294)

lower than 7.421 mg L–1. The AgIZBEN complex showed the most promising anti-tuberculosis

action, with MIC90 of 0.956 mg L–1 and selectivity index (SI) = 29.3 while the AgIZpAN showed

SI higher than 460 and MIC90 of 1.077 mg L–1. The free acylhydrazones derivatives also showed

SI higher than 20.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{A.D'Oliveira2025,

title = {Silver-dichloroquinoline Complexes: Synthesis, Structure and Antitubercular Properties},

author = {Kaíque A. D'Oliveira and Nícolas Glanzmann and Adilson D. da Silva and Carlos E. T. Bruzeguini and Marcos A. Ribeiro and Christian S. C. Canales and Cesar A. Roque-Borda and Fernando R. Pavan and Pedro P. Corbi and Norberto Masciocchi and Alexandre Cuin},

doi = {10.21577/0103-5053.20250048},

issn = {1678-4790},

year  = {2025},

date = {2025-00-00},

urldate = {2025-00-00},

journal = {J. Braz. Chem. Soc.},

publisher = {Sociedade Brasileira de Quimica (SBQ)},

abstract = {<jats:p>Synthesis, characterization, and antitubercular activity of three silver(I) complexes

with 4,7-dichloroquinoline (C9H5Cl 2N, DCQ), 2,2’-bipyridine (C10H8N2, Bpy)

and triphenylphosphine (C18H15P, PPh3) are presented. Complex 1 was formulated as

[Ag(H2O)(DCQ)2(μ-ONO2)Ag(NO3)(DCQ)2], 1:2 M:L1 molar ratio, L1 = DCQ. Complexes 2

[Ag(NO3)(DCQ)(Bpy)] and 3 [Ag(NO3)(DCQ)(PPh3)]2 exhibit 1:1:1 M:L1:L2 molar ratio, where

L2 = Bpy or PPh3. All compounds were analytically, spectroscopically, and structurally

characterized. The crystal and molecular structures of complexes 1 and 3 were determined by

conventional single-crystal X-ray diffraction, while the crystal structure of 2 was elucidated using

laboratory powder diffraction method. Elemental analyses, conductometry, infrared (IR), Raman,

UV-Vis, and 1

H, 13C{1

H}, 31P{1

H}, {1

H-15N} heteronuclear multiple bond correlation (HMBC)

nuclear magnetic resonance (NMR) spectroscopies, along with 1

H NMR T1 relaxation time

measurements, corroborate the proposed formulas. Complex 3, in the solid state, was found to

contain significant residual solvents (CH3OH and CH3CN). Consequently, its desolvation process

was investigated using IR microscopy and X-ray powder diffraction. In vitro biological assays

against Mycobacterium tuberculosis H37Rv (ATCC 27294) were performed for all compounds.

Complexes 1 and 3 shown the lowest concentration of the antibiotic at which 90% of the isolates

are inhibited (MIC90) of 7 ± 1 and 14 ± 3 µg mL–1, suggesting their potential as antimycobacterial

agents, in contrast, assays indicate lower activity for compound 2 against the evaluated strains.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Rezende2024,

title = {Coordination Compounds as Antivirals against Neglected Tropical Diseases},

author = {Wallace S. Rezende and Antonio Marçal Neto and Juliano J. Corbi and Pedro P. Corbi and Raphael E. F. de Paiva and Fernando R. G. Bergamini},

doi = {10.1002/cmdc.202400799},

issn = {1860-7187},

year  = {2024},

date = {2024-12-09},

urldate = {2024-12-09},

journal = {ChemMedChem},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:p>Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen‐related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate‐to‐cold environments. The slow‐paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS‐CoV‐2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod‐borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Mendonça2024d,

title = {Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents},

author = {Fernanda Ferreira Mendonça and Danielle Vieira Sobral and Ana Claudia Ranucci Durante and Ana Cláudia Camargo Miranda and Jorge Mejia and Daniele de Paula Faria and Fabio Luiz Navarro Marques and Marycel Figols de Barboza and Leonardo Lima Fuscaldi and Luciana Malavolta},

doi = {10.1007/s00726-023-03379-x},

issn = {1438-2199},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Amino Acids},

volume = {56},

number = {1},

publisher = {Springer Science and Business Media LLC},

abstract = {<jats:title>Abstract</jats:title><jats:p>Breast cancer remains a pressing public health issue primarily affecting women. Recent research has spotlighted bioactive peptides derived from laminin-111, implicated in breast tumor development. Remarkably, the sequences IKVAV, YIGSR, and KAFDITYVRLKF from the α1, β1, and γ1 chains, respectively, have garnered significant attention. This study aims to assess the potential of these radiolabeled peptides as targeting agents for breast cancer. The three peptides were synthesized using the Fmoc strategy, purified via reversed-phase high-performance liquid chromatography (RP-HPLC), and characterized through mass spectrometry. Iodine-131 (<jats:sup>131</jats:sup>I) radiolabeling was performed using the chloramine T method, exhibiting high radiochemical yield and stability for [<jats:sup>131</jats:sup>I]I-YIKVAV and [<jats:sup>131</jats:sup>I]I-YIGSR. Conversely, [<jats:sup>131</jats:sup>I]I-KAFDITYVRLKF demonstrated low radiochemical yield and stability and was excluded from the biological studies. The lipophilicity of the compounds ranged from − 2.12 to − 1.10. Serum protein binding assay for [<jats:sup>131</jats:sup>I]I-YIKVAV and [<jats:sup>131</jats:sup>I]I-YIGSR reached ≅ 48% and ≅ 25%, respectively. Affinity for breast cancer cells was evaluated using MDA-MB-231 and MCF-7 tumor cell lines, indicating the affinity of the radiopeptides with these tumor cells. Ex vivo biodistribution profiles of the radiopeptides were assessed in the MDA-MB-231 breast tumor animal model, revealing tumor tissue accumulation, supported by a high tumor-to-contralateral muscle ratio and autoradiography. These results signify the effective penetration of YIKVAV and YIGSR into tumor tissue. Therefore, the synthesized α1 and β1 peptide fragments exhibit favorable characteristics as potential breast cancer-targeting agents, promising future exploration as radiopharmaceuticals for breast cancer.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Machado2024,

title = {A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel},

author = {Raiane Aparecida dos Santos Machado and Raoni Pais Siqueira and Fernanda Cardoso da Silva and André Carlos Pereira de Matos and Dayanne Silva Borges and Gislaine Gonçalves Rocha and Thais Cristina Prado de Souza and Rafael Aparecido Carvalho Souza and Clayton Rodrigues de Oliveira and Antônio G. Ferreira and Pedro Ivo da Silva Maia and Victor Marcelo Deflon and Carolina Gonçalves Oliveira and Thaise Gonçalves Araújo},

doi = {10.3390/pharmaceutics16121610},

issn = {1999-4923},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Pharmaceutics},

volume = {16},

number = {12},

publisher = {MDPI AG},

abstract = {<jats:p>Background/Objectives: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of breast cancer (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity to conventional drugs. Zinc is an important trace element for homeostasis, and its Schiff base metal complexes have shown promise in treating advanced tumors. In this study, four new heteroleptic Zn(II) complexes (1–4) with Schiff bases were synthesized, characterized, and evaluated for their activity in BC cells. Methods: Compounds were synthesized, characterized, and their crystal structures were determined. Biological activity was assessed using MTT, clonogenic, scratch wound healing, caspase 3 and 8 activity, qPCR, and chemosensitization assays. Results: The complexes exhibited cytotoxicity against MCF-7 (luminal BC), MDA-MB-453 (HER2-positive BC), and MDA-MB-231 (TNBC) cell lines, with IC50 values ranging from 0.01 to 20 µM. Complex 4 showed reduced cytotoxicity toward non-tumor cell lines. This, complexation with Zn(II) increased the cytotoxicity of the ligands, a trend not observed for complexes 1–3. Due to its favorable profile, complex 4 was selected for further assays, in which it inhibited colony formation and the cell migration of TNBC cells in a dose-dependent manner. Furthermore, this compound induced cell death independently of caspases, decreasing the activity of caspase 8. Interestingly, complex 4 sensitized TBNC cells to doxorubicin and paclitaxel, possibly modulating the epithelial–mesenchymal transition mechanism, as evidenced by increased CDH1 expression. Conclusions: Results suggest the potential of complex 4 in sensitizing aggressive BC cells to chemotherapy, proving to be a promising alternative in cases of therapeutic failure.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Silva2024b,

title = {Antiviral Activity of Pd(II) Complexes with Aminoadamantanes Against Arboviruses},

author = {Laura Barros Silva and Állefe Barbosa Cruz and Douglas Henrique Pereira and Natasha Marques Cassani and Uriel Enrique Aquino Ruiz and Igor Andrade Santos and Daniel Oliveira Silva Martins and Douglas Hideki Nakahata and Déborah de Alencar Simoni and Ioannis Kanavos and Luisa Ronga and Ryszard Lobinski and Anna Karla dos Santos Pereira and Ana Carolina Gomes Jardim and Raphael Enoque Ferraz de Paiva and Pedro Paulo Corbi},

doi = {10.1002/slct.202404225},

issn = {2365-6549},

year  = {2024},

date = {2024-10-04},

urldate = {2024-10-04},

journal = {ChemistrySelect},

volume = {9},

number = {37},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title>

                  <jats:p>

                    In this paper, we report the synthesis, structural characterization, and antiviral properties of palladium(II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass spectrometric analyses indicated a 1:2 metal/ligand ratio. The single crystal data for Pd‐mtn revealed that the complex adopts a square geometry with the two memantine ligands bonded to Pd(II) by the nitrogen atoms of the NH

                    <jats:sub>2</jats:sub>

                    group, in a

                    <jats:italic>trans</jats:italic>

                    configuration. Computational studies supported a similar structure for Pd‐atd. The complexes were stable in DMSO solution for 24 h. The antiviral properties of Pd‐atd and Pd‐mtn were evaluated against

                    <jats:italic>Zika</jats:italic>

                    (ZIKV) and

                    <jats:italic>Chikungunya</jats:italic>

                    (CHIKV)

                    <jats:italic>viruses</jats:italic>

                    in vitro at their highest noncytotoxic concentrations. The Pd‐atd (at 2 µM) and Pd‐mtn (at 10 µM) complexes were able to impair 76% and 96% of CHIKV replication, respectively, which points the coordination of amantadine and memantine to Pd(II) as a successful strategy to increase their anti‐CHIKV properties. Conversely, the Pd(II) complexes did not significantly inhibit the replication of ZIKV, which confirms the selectivity towards CHIKV. Interaction of the compounds with

                    <jats:italic>N</jats:italic>

                    ‐acetyl‐

                    <jats:sc>l</jats:sc>

                    ‐cysteine, a model disulfide‐containing peptide, and plasmid DNA pointed to Cys‐containing peptides as more likely targets than nucleotides for the complexes.

                  </jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Martins2024,

title = {Exploring the antiviral activities of the FDA-approved drug sulfadoxine and its derivatives against Chikungunya virus},

author = {Daniel Oliveira Silva Martins and Uriel Enrique Aquino Ruiz and Igor Andrade Santos and Igor Santos Oliveira and Marco Guevara-Vega and Raphael Enoque Ferraz de Paiva and Camilla Abbehausen and Robinson Sabino-Silva and Pedro Paulo Corbi and Ana Carolina Gomes Jardim},

doi = {10.1007/s43440-024-00635-z},

issn = {2299-5684},

year  = {2024},

date = {2024-10-00},

urldate = {2024-10-00},

journal = {Pharmacol. Rep},

volume = {76},

number = {5},

pages = {1147--1159},

publisher = {Springer Science and Business Media LLC},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{RodriguesToledo2024,

title = {EGFR- and Integrin αVβ3-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics},

author = {Cibele Rodrigues Toledo and Ahmed A. Tantawy and Leonardo Lima Fuscaldi and Luciana Malavolta and Carolina de Aguiar Ferreira},

doi = {10.3390/ijms25158553},

issn = {1422-0067},

year  = {2024},

date = {2024-08-00},

urldate = {2024-08-00},

journal = {IJMS},

volume = {25},

number = {15},

publisher = {MDPI AG},

abstract = {<jats:p>The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These agents exploit the overexpression or mutations of specific receptors, such as the Epidermal Growth Factor receptor (EGFR) and αVβ3 integrin, which are pivotal in tumor growth, angiogenesis, and metastasis. Despite the extensive research into and promising outcomes associated with antibody-based therapies, peptides offer a compelling alternative due to their smaller size, ease of modification, and rapid bioavailability, factors which potentially enhance tumor penetration and reduce systemic toxicity. However, the application of peptides in clinical settings has challenges. Their lower binding affinity and rapid clearance from the bloodstream compared to antibodies often limit their therapeutic efficacy and diagnostic accuracy. This overview sets the stage for a comprehensive review of the current research landscape as it relates to EGFR- and integrin αVβ3-targeting peptides. We aim to delve into their synthesis, radiolabeling techniques, and preclinical and clinical evaluations, highlighting their potential and limitations in cancer theranostics. This review not only synthesizes the extant literature to outline the advancements in peptide-based agents targeting EGFR and integrin αVβ3 but also identifies critical gaps that could inform future research directions. By addressing these gaps, we contribute to the broader discourse on enhancing the diagnostic precision and therapeutic outcomes of cancer treatments.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Candido2024,

title = {Crystal Structure and Anti-Proliferative and Mutagenic Evaluation of the Palladium(II) Complex of Deoxyalliin},

author = {Tuany Zambroti Candido and Mariana Mazzo Quintanilha and Bianca Alves Schimitd and Déborah de Alencar Simoni and Douglas Hideki Nakahata and Raphael Enoque Ferraz de Paiva and Igor Henrique Cerqueira and Flávia Aparecida Resende and João Ernesto Carvalho and Ana Lucia Tasca Gois Ruiz and Carmen Silvia Passos Lima and Pedro Paulo Corbi},

doi = {10.3390/inorganics12070194},

issn = {2304-6740},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {Inorganics},

volume = {12},

number = {7},

publisher = {MDPI AG},

abstract = {<jats:p>Platinum(II) and palladium(II) complexes have been investigated as potential anticancer drugs since the serendipitous discovery of the antineoplastic activities of cisplatin in the 1960s. Skin cancer is considered the most common malignant neoplasm that affects humans, and melanoma is the most lethal type of skin cancer. Surgical excision is the main form of treatment, which also may include radiotherapy, systemic chemotherapy, and immunotherapy. In this work, new insights concerning the structural characterization and in vitro anti-proliferative activity of the palladium(II) complex with the amino acid deoxyalliin (Pd-sac) against a panel of thirteen human tumor cells, with emphasis on skin cancer cell lines, are presented. The composition of the complex was confirmed by elemental analysis as [Pd(C6H10NO2S)2]. The structure of the complex was elucidated for the first time by a single-crystal X-ray diffraction technique. Each deoxyalliin molecule coordinates in a bidentate N,S-mode to palladium(II) in a trans-configuration analogous to the platinum(II) deoxyalliin complex early reported. As the main result, the Pd-sac complex showed a selective anti-proliferative activity against melanoma (UACC-62, TGI = 63.5 µM), while both deoxyalliin and K2PdCl4 were inactive against all cell lines. Moreover, Pd-sac did not affect the proliferation of non-tumorigenic keratinocytes (HaCaT, TGI > 586 µM) and was non-mutagenic in the Ames assay. The results open new perspectives for in vivo studies concerning the application of the Pd-sac complex in the treatment of melanoma.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Marinho2024,

title = {Development and validation of Mayaro virus with luciferase reporter genes as a tool for antiviral assays},

author = {Mikaela dos Santos Marinho and Ya-Nan Zhang and Natasha Marques Cassani and Igor Andrade Santos and Ana Laura Costa Oliveira and Anna Karla dos Santos Pereira and Pedro Paulo Corbi and Bo Zhang and Ana Carolina Gomes Jardim},

doi = {10.1016/j.heliyon.2024.e33885},

issn = {2405-8440},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {Heliyon},

volume = {10},

number = {13},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Ferreira2024,

title = {A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells},

author = {Helen Soares Valença Ferreira and Luana Munique Sousa Ramos and Fernanda Cardoso Silva and Daniel Lima Alves and Gabriele de Menezes Pereira and Pedro Henrique de Oliveira Santiago and Angelina Maria de Almeida and Javier Ellena and Pedro Paulo Corbi and Carolina Gonçalves Oliveira and Mauro Vieira de Almeida and Cristina Ribas Fürstenau and Dayanne Silva Borges and Raoni Pais Siqueira and Wendell Guerra and Thaise Gonçalves Araújo},

doi = {10.1016/j.jinorgbio.2024.112524},

issn = {0162-0134},

year  = {2024},

date = {2024-06-00},

urldate = {2024-06-00},

journal = {Journal of Inorganic Biochemistry},

volume = {255},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Borges2024,

title = {Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide/Thiourea Ligands as Potential Leishmanicidal Agents},

author = {Alice P. Borges and Malu M. S. Obata and Silvia H. Libardi and Rafael O. Trevisan and Victor M. Deflon and Ulrich Abram and Francis B. Ferreira and Luiz Antônio S. Costa and Antonio O. T. Patrocínio and Marcos V. da Silva and Júlio C. Borges and Pedro I. S. Maia},

doi = {10.3390/pharmaceutics16040452},

issn = {1999-4923},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Pharmaceutics},

volume = {16},

number = {4},

publisher = {MDPI AG},

abstract = {<jats:p>Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of complexes derived from MI metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HLR) were obtained by reactions of p-toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with AgI and AuI, leading to the formation of complexes of composition [M(HLR)2]X (M = Ag or Au; X = NO3− or Cl−). All compounds were characterized by FTIR, 1H NMR, UV-vis, emission spectroscopy and elemental analysis. Some representatives were additionally studied by ESI-MS and single-crystal XRD. Their properties were further analyzed by DFT calculations. Their cytotoxicity on Vero cells and the extracellular leishmanicidal activity on Leishmania infantum and Leishmania braziliensis cells were evaluated. Additionally, the interaction of the complexes with the Old Yellow enzyme of the L. braziliensis (LbOYE) was examined. The biological tests showed that some compounds present remarkable leishmanicidal activity, even higher than that of the standard drug Glucantime, with different selectivity for the two species of Leishmania. Finally, the interaction studies with LbOYE revealed that this enzyme could be one of their biological targets.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Amaral2024c,

title = {Synthesis, spectroscopic and structural characterizations and in vitro antimycobacterial activity of silver(I) complexes with sulfapyridine (SPY) and sulfamerazine (SM)},

author = {Thaeny Costa Amaral and Nícolas Glanzmann and Adilson D. da Silva and Gabriele de M. Pereira and Pedro P. Corbi and Christian S.C. Canales and Fernando R. Pavan and Kaíque A.D. Oliveira and Alexandre Cuin},

doi = {10.1016/j.molstruc.2023.137234},

issn = {0022-2860},

year  = {2024},

date = {2024-03-00},

urldate = {2024-03-00},

journal = {Journal of Molecular Structure},

volume = {1300},

publisher = {Elsevier BV},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}