Lista completa de Publicações

@article{Rezende2024,

title = {Coordination Compounds as Antivirals against Neglected Tropical Diseases},

author = {Wallace S. Rezende and Antonio Marçal Neto and Juliano J. Corbi and Pedro P. Corbi and Raphael E. F. de Paiva and Fernando R. G. Bergamini},

doi = {10.1002/cmdc.202400799},

issn = {1860-7187},

year  = {2024},

date = {2024-12-09},

urldate = {2024-12-09},

journal = {ChemMedChem},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:p>Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen‐related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate‐to‐cold environments. The slow‐paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS‐CoV‐2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod‐borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Lima2024b,

title = {Theranostics Nuclear Medicine in Prostate Cancer},

author = {Helena Lima and Marina Etchebehere and Mateos Bogoni and Caroline Torricelli and Ellen Nogueira-Lima and Victor M. Deflon and Mariana Lima and Elba Etchebehere},

doi = {10.3390/ph17111483},

issn = {1424-8247},

year  = {2024},

date = {2024-11-00},

urldate = {2024-11-00},

journal = {Pharmaceuticals},

volume = {17},

number = {11},

publisher = {MDPI AG},

abstract = {<jats:p>Theranostic Nuclear Medicine is based on the idea of combining the same molecule (or drug) with different radioisotopes for both diagnosis and treatment, a concept that emerged in the early 1940s with the use of radioactive iodine for thyroid diseases. Theranostic Nuclear Medicine has since expanded to diseases of higher incidence, such as prostate cancer, with several imaging methods used to assess the extent of the disease and the corresponding radiopharmaceuticals used for treatment. For example, by detecting osteoblastic metastases by bone scintigraphy, corresponding radiopharmaceuticals with therapeutic properties can be administered to eliminate or reduce pain associated with metastases and/or determine overall survival gain. The purpose of this review is to discuss the role of Theranostic Nuclear Medicine in prostate cancer, addressing the main diagnostic imaging studies with their corresponding treatments in the Theranostic model.</jats:p>},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39366100,

title = {Antibacterial profile and antiproliferative activities over human tumor cells of new silver(I) complexes containing two distinct trifluoromethyl uracil isomers},

author = {Gabriele de Menezes Pereira and Julia H Bormio Nunes and Vinicius Souza Macedo and Douglas Henrique Pereira and Kaio Eduardo Buglio and Daniele D Affonso and Ana Lucia T G Ruiz and João Ernesto de Carvalho and Silmara Cristina L Frajácomo and Wilton R Lustri and Carmen Silvia Passos Lima and Fernando R G Bergamini and Alexandre Cuin and Norberto Masciocchi and Pedro Paulo Corbi},

doi = {10.1016/j.jinorgbio.2024.112752},

issn = {1873-3344},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-01},

journal = {J Inorg Biochem},

volume = {262},

pages = {112752},

abstract = {New silver(I) complexes of 5-(trifluoromethyl)uracil (5TFMU) and 6-(trifluoromethyl)uracil (6TFMU) isomers were synthesized, characterized, and evaluated as antibacterial and antiproliferative agents. Based on elemental and thermogravimetric analyses, the Ag-5TFMU and Ag-6TFMU species are formulated as AgCHFNO and AgCHFNO, respectively. Infrared and C solid-state nuclear magnetic resonance spectroscopies suggest coordination of the trifluoromethyluracil isomers to silver by both nitrogen and oxygen atoms. Confirmation of their structure and connectivity was achieved, in the absence of single crystals of suitable quality, by state-of-the-art structural powder diffraction methods. In Ag-5TFMU, the organic ligand is tridentate and two distinct metal coordination environments are found (linear AgN as well as C AgO geometries), whereas Ag-6TFMU contains a complex polymeric structure with tetradentate dianionic 6TFMU moieties and five distinct AgX (X = N, O) fragments, further stabilized by ancillary (longer) AgO contacts. These species presented modest activity over Gram-positive and Gram-negative bacterial strains, whereas Ag-6TFMU was active over a set of tumor cells, with the best activity over prostate (PC-3) and kidney cell lines and selectivity indices of 4.6 and 1.3, respectively. On the other hand, Ag-5TFMU was active over all considered tumor cells except MCF-7 (breast cancer). The best activity was found for PC-3 cells, but no selectivity was observed. The Ag-5TFMU and Ag-6TFMU species also reduced the proliferation of tongue squamous cell carcinoma cell lines SCC - 4 and SCC-15. Preliminary biophysical assays by circular dichroism suggest that the Ag-5TFMU complex interacts with DNA by intercalation, an effect not seen in Ag-6TFMU.},

keywords = {Área Pré-Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{RodriguesToledo2024,

title = {EGFR- and Integrin αVβ3-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics},

author = {Cibele Rodrigues Toledo and Ahmed A. Tantawy and Leonardo Lima Fuscaldi and Luciana Malavolta and Carolina de Aguiar Ferreira},

doi = {10.3390/ijms25158553},

issn = {1422-0067},

year  = {2024},

date = {2024-08-00},

urldate = {2024-08-00},

journal = {IJMS},

volume = {25},

number = {15},

publisher = {MDPI AG},

abstract = {<jats:p>The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These agents exploit the overexpression or mutations of specific receptors, such as the Epidermal Growth Factor receptor (EGFR) and αVβ3 integrin, which are pivotal in tumor growth, angiogenesis, and metastasis. Despite the extensive research into and promising outcomes associated with antibody-based therapies, peptides offer a compelling alternative due to their smaller size, ease of modification, and rapid bioavailability, factors which potentially enhance tumor penetration and reduce systemic toxicity. However, the application of peptides in clinical settings has challenges. Their lower binding affinity and rapid clearance from the bloodstream compared to antibodies often limit their therapeutic efficacy and diagnostic accuracy. This overview sets the stage for a comprehensive review of the current research landscape as it relates to EGFR- and integrin αVβ3-targeting peptides. We aim to delve into their synthesis, radiolabeling techniques, and preclinical and clinical evaluations, highlighting their potential and limitations in cancer theranostics. This review not only synthesizes the extant literature to outline the advancements in peptide-based agents targeting EGFR and integrin αVβ3 but also identifies critical gaps that could inform future research directions. By addressing these gaps, we contribute to the broader discourse on enhancing the diagnostic precision and therapeutic outcomes of cancer treatments.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Almeida2024,

title = {Radioligand Therapy in Lymphoma},

author = {Ludmila Santiago Almeida and Roberto C. Delgado Bolton and Victor Cabral Heringer and Samuel de Souza Medina and Elba Etchebehere},

doi = {10.1016/j.cpet.2024.05.003},

issn = {1556-8598},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {PET Clinics},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Candido2024,

title = {Crystal Structure and Anti-Proliferative and Mutagenic Evaluation of the Palladium(II) Complex of Deoxyalliin},

author = {Tuany Zambroti Candido and Mariana Mazzo Quintanilha and Bianca Alves Schimitd and Déborah de Alencar Simoni and Douglas Hideki Nakahata and Raphael Enoque Ferraz de Paiva and Igor Henrique Cerqueira and Flávia Aparecida Resende and João Ernesto Carvalho and Ana Lucia Tasca Gois Ruiz and Carmen Silvia Passos Lima and Pedro Paulo Corbi},

doi = {10.3390/inorganics12070194},

issn = {2304-6740},

year  = {2024},

date = {2024-07-00},

urldate = {2024-07-00},

journal = {Inorganics},

volume = {12},

number = {7},

publisher = {MDPI AG},

abstract = {<jats:p>Platinum(II) and palladium(II) complexes have been investigated as potential anticancer drugs since the serendipitous discovery of the antineoplastic activities of cisplatin in the 1960s. Skin cancer is considered the most common malignant neoplasm that affects humans, and melanoma is the most lethal type of skin cancer. Surgical excision is the main form of treatment, which also may include radiotherapy, systemic chemotherapy, and immunotherapy. In this work, new insights concerning the structural characterization and in vitro anti-proliferative activity of the palladium(II) complex with the amino acid deoxyalliin (Pd-sac) against a panel of thirteen human tumor cells, with emphasis on skin cancer cell lines, are presented. The composition of the complex was confirmed by elemental analysis as [Pd(C6H10NO2S)2]. The structure of the complex was elucidated for the first time by a single-crystal X-ray diffraction technique. Each deoxyalliin molecule coordinates in a bidentate N,S-mode to palladium(II) in a trans-configuration analogous to the platinum(II) deoxyalliin complex early reported. As the main result, the Pd-sac complex showed a selective anti-proliferative activity against melanoma (UACC-62, TGI = 63.5 µM), while both deoxyalliin and K2PdCl4 were inactive against all cell lines. Moreover, Pd-sac did not affect the proliferation of non-tumorigenic keratinocytes (HaCaT, TGI > 586 µM) and was non-mutagenic in the Ames assay. The results open new perspectives for in vivo studies concerning the application of the Pd-sac complex in the treatment of melanoma.</jats:p>},

keywords = {Área Básica},

pubstate = {published},

tppubtype = {article}

}

@article{Siqueira2024,

title = {TRATAMENTO BEM-SUCEDIDO DE PACIENTE COM DIAGNÓSTICO DE VIPOMA METASTÁTICO COM TRATAMENTO TERANÓSTICO OCTREOTATO-DOTA-177 LUTÉCIO},

author = {Nadia Sclearuc de Siqueira and Helena Paes Almeida Saito and Felipe Osorio Costa and Everton Cazzo and Allan Oliveira Santos and Jose Barreto Campello Carvalheira},

doi = {10.1016/j.htct.2024.04.097},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Liveraro2024,

title = {DEEP LEARNING FOR CT IMAGES SEGMENTATION},

author = {Gianni Shigeru Setoue Liveraro and Maria Emília Seren Takahashi and Fabiana Lascala and Maria Carolina Santos Mendes and Jun Takahashi and José Barreto Campello Carvalheira},

doi = {10.1016/j.htct.2024.04.058},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Heringer2024d,

title = {ARTIFICIAL INTELLIGENCE TO EVALUATE METABOLIC TUMOR BURDEN IN PRIMARY STAGING OF RECTAL CANCER WITH 18F-FDG PET/CT},

author = {Victor Cabral Costa Ribeiro Heringer and Maria Carolina S. Mendes and Barbara Juarez Amorim and Allan Oliveira Santos and Marina N. Silveira and Cleide Silva and Juliano S. Fonseca and Mariana C.L. Lima and Lorena P. Cunha and Carlos Augusto R. Martinez and Claudio Coy and Jose Barreto C. Carvalheira and Elba Cristina Sá de Camargo Etchebehere},

doi = {10.1016/j.htct.2024.04.054},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S3--S4},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Reis2024,

title = {COMPARISON OF 68GA-PSMA AND 18F-FDG-PET/CT IN THE ASSESSMENT OF DESMOID TUMORS},

author = {Tobias Luis dos Reis and Kaique Moraes do Amaral and Najua Abou Arab and Maria Emilia Seren Takahashi and José Barreto Campello Carvalheira and Barbara Juarez Amorim and Elba Cristina Sá de Camargo Etchebehere and Mariana da Cunha Lopes de Lima and Allan de Oliveira Santos and Ludmila Santiago Almeida and Eliana Cristina Martins Miranda and Carmen Silvia Passos Lima and Celso Dario Ramos and Sérgio Querino Brunetto and Simone Kuba and NAtália Tobar and Carmino Antonio Souza and Mariana Cortês Caleffi and Mariana Fernandes França Mitre Amorim},

doi = {10.1016/j.htct.2024.04.080},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S19--S20},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Amaral2024b,

title = {TREATMENT OF REFRACTORY MULTIPLE MYELOMA WITH PSMA-177LU: A CASE REPORT},

author = {Kaique M. Amaral and Felipe P.G. Ribeiro and Fernando V.P. Souza and Allan O. Santos and Sergio Q. Brunetto and Maria Emilia S. Takahashi and Vania P. Castro and Carmem S.P. Lima and Barbara J. Amorim and Carmino A. Souza and Celso D. Ramos},

doi = {10.1016/j.htct.2024.04.104},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Heringer2024c,

title = {THE ROLE OF PET/CT IN DETECTING OCCULT DISEASE IN SYNCHRONOUS TUMORS: A CASE REPORT OF MERKEL CELL CARCINOMA AND NON-HODGKIN LYMPHOMA},

author = {Victor C.C.R. Heringer and Fabíola F. Zarpelão and Kaique M. Amaral and Nájua A.A. Silveira and Ricardo N. Tineo and Thais A. Tognoli and Dihego F. Santos and Felipe P.G. Ribeiro and Thiago F. Souza and Mariana Lima and Allan O. Santos and Barbara J. Amorim and Elba C.S.C. Etchebehere and Ludmila S. Almeida and Carmen S.P. Lima and Jose B.C. Carvalheira and Celso D. Ramos},

doi = {10.1016/j.htct.2024.04.100},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Takahashi2024,

title = {COMPARISON OF IBI AND PBI CALCULATED FOR 68GA-PSMA AND 18F-FDG IN MULTIPLE MYELOMA PATIENTS},

author = {Maria Emilia Seren Takahashi and Stephan P.M. Souza and Fernanda C. Frasson and Gislaine B. Oliveira and Vania P. Castro and Fernando V. Pericole and Lício A. Velloso and Cármino A. Souza and Irene G.H. Lorand-Metze and Allan O. Santos and Celso Darío Ramos},

doi = {10.1016/j.htct.2024.04.087},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Amaral2024,

title = {DUAL-TRACER PET/CT IN MYELOFIBROSIS: A CASE SERIES ANALYSIS USING 18F-FDG AND 18F-PSMA PET/CT},

author = {Kaique M. Amaral and Katia B.B. Pagnano and Victor Cabral Costa Ribeiro Heringer and Sergio Q. Brunetto and Simone Kuba and Maria Emilia S. Takahashi and Allan O. Santos and Barbara J. Amorim and Elba C.S.C. Etchebehere and Mariana C.L. Lima and Carmino A. Souza and Celso D. Ramos},

doi = {10.1016/j.htct.2024.04.109},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Tineo2024,

title = {COMPARISON BETWEEN PET/CT WITH 18F-PSMA-1007 AND WITH 18F-FDG IN MUSCLE-INVASIVE BLADDER UROTHELIAL CARCINOMA},

author = {Ricardo Norberto Tineo and Natalia Dalsenter Avilez and Juliano Tomé Rodrigues and Felipe Piccarone G Ribeiro and Helena Paes de Alm de Saito and Frederico Leal and Barbara Juazer Amorim and Jose Barrreto C. Carvalheira and Leonardo Oliveira Reis and Celso Dario Ramos},

doi = {10.1016/j.htct.2024.04.086},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S23--S24},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Silveira2024,

title = {COMPARISON OF 18F-FDG AND 18F-PSMA PET/CT IN PATIENTS WITH NON-SMALL CELL LUNG CANCER},

author = {Najua Abou Arabi Silveira and Maurício Wesley Perroud Júnior and Hugo Nakano Ide and Kaique Moraes do Amaral and Simone Kuba and Natália Tobar and Thiago Ferreira de Souza and Carmen Silva Passos Lima and José Barreto Campello Carvalheira and Barbara Juarez Amorim and Elba Cristina Sá de Camargo Etchebehere and Mariana da Cunha Lopes de Lima and Allan de Oliveira Santos and Ludimila Santiago Almeida and Maria Emília Seren Takahashi and Eliana Cristina Martins Miranda and Carmino Antonio de Souza and Sérgio Querino Brunetto and Celso Dario Ramos},

doi = {10.1016/j.htct.2024.04.079},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{HERINGER2024b,

title = {RADIOLIGAND THERAPY IN LYMPHOMA: PAST, PRESENT AND FUTURE},

author = {Victor C.C.R. HERINGER and Ludmila S. ALMEIDA and Roberto C. DELGADO BOLTON and Daniel C. PANCIEIRA and Samuel S MEDINA and Elba C.S.C. ETCHEBEHERE},

doi = {10.1016/j.htct.2024.04.115},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{ETCHEBEHERE2024,

title = {THERANOSTICS: NUCLEAR MEDICINE IN PROSTATE CANCER},

author = {Marina Camargo ETCHEBEHERE and Helena da Cunha Lopes DE LIMA and Mariana da Cunha Lopes DE LIMA and Elba Cristina Sá de Camargo ETCHEBEHERE},

doi = {10.1016/j.htct.2024.04.111},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{Heringer2024,

title = {177LU-PSMA IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER: PRELIMINARY ANALYSIS OF A BRAZILIAN MULTICENTRIC STUDY},

author = {Victor Cabral Costa Ribeiro Heringer and Felipe P.G. Ribeiro and Diogo Bastos and Camila Mosci and Dalton A. Anjos and Paulo Almeida Filho and Gustavo Gomes and Filipe Villela-Pedras and Fabio Ribeiro and Julio Correia and José F. Marin and Carlos Buchpiguel and Elba C.S.C. Etchebehere},

doi = {10.1016/j.htct.2024.04.071},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}

@article{doNascimento2024,

title = {18F-FLUORIDE PET/CT vs 18F-PSMA-1007 TO DETECT BONE METASTASES IN PROSTATE CANCER – A HEAD-TO-HEAD PROSPECTIVE COMPARISON},

author = {Beatriz Birelli do Nascimento and Allan Santos and Natalia Tobar and Fabiana Mori and Mariana Camacho and Mariana Lima and Edna Brunetto and Sergio Brunetto and Anelise Ruzzarin and Juliana Ciampi and Marina Silveira and Gardenia Oliveira Barbosa and Wagner Matheus and Ubirajara Ferreira and Elba Etchebehere},

doi = {10.1016/j.htct.2024.04.088},

issn = {2531-1379},

year  = {2024},

date = {2024-04-00},

urldate = {2024-04-00},

journal = {Hematology, Transfusion and Cell Therapy},

volume = {46},

pages = {S24--S25},

publisher = {Elsevier BV},

keywords = {Área Clínica},

pubstate = {published},

tppubtype = {article}

}