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da Silva Veras Sousa, Hádila; Heringer, Victor Cabral Costa Ribeiro; Perin, Matheus Yung; Silveira, Nájua Abou Arabi; Kuba, Simone; Macedo, Ligia Traldi; Lourenço, Gustavo Jacob; Chone, Carlos Takahiro; de Souza, Carmino Antônio; Ramos, Celso Dario; Lima, Carmen Silvia Passos
Head-to-head comparison of 18F-PSMA and 18F-FDG PET/CT in locoregionally advanced head and neck squamous cell carcinoma: a pilot study Journal Article
Em: Brazilian Journal of Otorhinolaryngology, vol. 92, não 5, 2026, ISSN: 1808-8694.
Links | BibTeX | Tags: Área Clínica
@article{Sousa2026,
title = {Head-to-head comparison of 18F-PSMA and 18F-FDG PET/CT in locoregionally advanced head and neck squamous cell carcinoma: a pilot study},
author = {Hádila da Silva Veras Sousa and Victor Cabral Costa Ribeiro Heringer and Matheus Yung Perin and Nájua Abou Arabi Silveira and Simone Kuba and Ligia Traldi Macedo and Gustavo Jacob Lourenço and Carlos Takahiro Chone and Carmino Antônio de Souza and Celso Dario Ramos and Carmen Silvia Passos Lima},
doi = {10.1016/j.bjorl.2026.101863},
issn = {1808-8694},
year = {2026},
date = {2026-09-00},
urldate = {2026-09-00},
journal = {Brazilian Journal of Otorhinolaryngology},
volume = {92},
number = {5},
publisher = {Elsevier BV},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
von Zuben, Andrea Paula Bruno; do Carmo Ferreira, Maria; de Azevedo Barros, Marilisa Berti; Nativo, Juliana; Correa, M. Elvira P.; de Souza, Carmino Antônio
The impact of social inequalities on cancer incidence and mortality in a Brazilian City: Data from the population-based cancer registry Journal Article
Em: Cancer Epidemiology, vol. 103, 2026, ISSN: 1877-7821.
Links | BibTeX | Tags: Área Clínica
@article{vonZuben2026,
title = {The impact of social inequalities on cancer incidence and mortality in a Brazilian City: Data from the population-based cancer registry},
author = {Andrea Paula Bruno von Zuben and Maria do Carmo Ferreira and Marilisa Berti de Azevedo Barros and Juliana Nativo and M. Elvira P. Correa and Carmino Antônio de Souza},
doi = {10.1016/j.canep.2026.103102},
issn = {1877-7821},
year = {2026},
date = {2026-08-00},
urldate = {2026-08-00},
journal = {Cancer Epidemiology},
volume = {103},
publisher = {Elsevier BV},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Cunha, Pricila G; Takahashi, Maria Emilia Seren; Stucchi, Raquel S B; Ribeiro, Mariana Paixão; Souza, Thiago F; de Souza, Carmino Antonio; Amorim, Barbara Juarez; Moretti, Maria Luiza; Trabasso, Plinio; Ramos, Celso Dario
FDG-PET/CT Demonstrates Superior Detection of Multiorgan Involvement in Paracoccidioidomycosis Compared With Conventional Staging Journal Article
Em: 2026, ISSN: 1537-6591.
Resumo | Links | BibTeX | Tags: Área Clínica
@article{Cunha2026,
title = {FDG-PET/CT Demonstrates Superior Detection of Multiorgan Involvement in Paracoccidioidomycosis Compared With Conventional Staging},
author = {Pricila G Cunha and Maria Emilia Seren Takahashi and Raquel S B Stucchi and Mariana Paixão Ribeiro and Thiago F Souza and Carmino Antonio de Souza and Barbara Juarez Amorim and Maria Luiza Moretti and Plinio Trabasso and Celso Dario Ramos},
doi = {10.1093/cid/ciag372},
issn = {1537-6591},
year = {2026},
date = {2026-06-19},
urldate = {2026-06-19},
publisher = {Oxford University Press (OUP)},
abstract = {<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Paracoccidioidomycosis (PCM) is a neglected systemic mycosis in which accurate staging is critical but challenging with conventional methods. This study evaluated 18F-FDG PET/CT compared with standard evaluation for PCM staging and assessed its impact on disease severity classification.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Thirty-four patients with confirmed PCM (treatment-naïve or with suspected treatment failure) underwent conventional staging and whole-body 18F-FDG PET/CT. Disease severity was classified as mild, moderate, or severe. PET/CT images were analyzed qualitatively and quantitatively (SUVmax, TMLV, TLG).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>PET/CT detected more than twice as many lesions as conventional evaluation (150 vs 62; mean 4.4 ± 1.6 vs 1.8 ± 0.9 affected organ systems per patient), with statistically significant superiority for lymph node, pulmonary, and adrenal involvement (McNemar's test, P < .05). PET/CT reclassified 97% of patients as multifocal versus 59% by conventional staging and produced a significant unidirectional shift toward higher severity—the proportion classified as severe increased from 70.6% to 91.2% (P = .016). Patients with suspected treatment failure showed significantly lower TMLV and TLG than treatment-naïve patients (P < .05). Quantitative PET parameters correlated with serological titers and inflammatory markers (P < .05), and PET/CT detected four times as many sites as gallium-67 scintigraphy.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>18F-FDG PET/CT systematically reveals greater disease burden than conventional evaluation in PCM, reclassifying most patients toward higher severity with direct implications for treatment duration and follow-up. Where available, it should be considered an important complementary modality for initial disease assessment.</jats:p>
</jats:sec>},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Paracoccidioidomycosis (PCM) is a neglected systemic mycosis in which accurate staging is critical but challenging with conventional methods. This study evaluated 18F-FDG PET/CT compared with standard evaluation for PCM staging and assessed its impact on disease severity classification.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Thirty-four patients with confirmed PCM (treatment-naïve or with suspected treatment failure) underwent conventional staging and whole-body 18F-FDG PET/CT. Disease severity was classified as mild, moderate, or severe. PET/CT images were analyzed qualitatively and quantitatively (SUVmax, TMLV, TLG).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>PET/CT detected more than twice as many lesions as conventional evaluation (150 vs 62; mean 4.4 ± 1.6 vs 1.8 ± 0.9 affected organ systems per patient), with statistically significant superiority for lymph node, pulmonary, and adrenal involvement (McNemar's test, P < .05). PET/CT reclassified 97% of patients as multifocal versus 59% by conventional staging and produced a significant unidirectional shift toward higher severity—the proportion classified as severe increased from 70.6% to 91.2% (P = .016). Patients with suspected treatment failure showed significantly lower TMLV and TLG than treatment-naïve patients (P < .05). Quantitative PET parameters correlated with serological titers and inflammatory markers (P < .05), and PET/CT detected four times as many sites as gallium-67 scintigraphy.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>18F-FDG PET/CT systematically reveals greater disease burden than conventional evaluation in PCM, reclassifying most patients toward higher severity with direct implications for treatment duration and follow-up. Where available, it should be considered an important complementary modality for initial disease assessment.</jats:p>
</jats:sec>
Caleffi, Mariana; de Holanda Padilha, Daniela Morais; Bassete, Vinicius; Liveraro, Gianni; Alves, Pedro Henrique; Takahashi, Maria Emilia Seren; Kim, Leo Victor; Mendes, Maria Carolina Santos; Takahashi, Jun; Carvalheira, José Barreto Campello
Determination of a new gastric cancer mortality predictor based on body composition radiodensity variables Journal Article
Em: Clinical Nutrition ESPEN, vol. 73, 2026, ISSN: 2405-4577.
Links | BibTeX | Tags: Área Clínica
@article{Caleffi2026,
title = {Determination of a new gastric cancer mortality predictor based on body composition radiodensity variables},
author = {Mariana Caleffi and Daniela Morais de Holanda Padilha and Vinicius Bassete and Gianni Liveraro and Pedro Henrique Alves and Maria Emilia Seren Takahashi and Leo Victor Kim and Maria Carolina Santos Mendes and Jun Takahashi and José Barreto Campello Carvalheira},
doi = {10.1016/j.clnesp.2026.103132},
issn = {2405-4577},
year = {2026},
date = {2026-06-00},
urldate = {2026-06-00},
journal = {Clinical Nutrition ESPEN},
volume = {73},
publisher = {Elsevier BV},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
de Lima, Daniela Carneiro; Schönthal, Axel H.; da Fonseca, Clóvis Orlando Pereira; Reis, Fabiano; Lima, Carmen Silvia Passos; Foglio, Mary Ann
Protocol for a pilot-randomized trial in newly diagnosed glioblastoma: standard care with or without daily intranasal perillyl alcohol Journal Article
Em: Future Oncology, vol. 22, não 11, pp. 1263–1271, 2026, ISSN: 1744-8301.
Links | BibTeX | Tags: Área Clínica
@article{deLima2026,
title = {Protocol for a pilot-randomized trial in newly diagnosed glioblastoma: standard care with or without daily intranasal perillyl alcohol},
author = {Daniela Carneiro de Lima and Axel H. Schönthal and Clóvis Orlando Pereira da Fonseca and Fabiano Reis and Carmen Silvia Passos Lima and Mary Ann Foglio},
doi = {10.1080/14796694.2026.2652540},
issn = {1744-8301},
year = {2026},
date = {2026-05-03},
urldate = {2026-05-03},
journal = {Future Oncology},
volume = {22},
number = {11},
pages = {1263--1271},
publisher = {Informa UK Limited},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Takahashi, Maria Emilia S.; dos Santos, Tiago P.; Cralcev, Christopher; Miranda, Eliana; Silva, Marcos Paulo D. S.; Souza, Felipe C.; Carvalheira, José Barreto C.; de Souza, Carmino A.; Ramos, Celso Dario
Diagnostic brain-to-liver [18f]fdg uptake ratio predicts survival in multiple myeloma: A retrospective study Journal Article
Em: Eur J Nucl Med Mol Imaging, 2026, ISSN: 1619-7089.
Resumo | Links | BibTeX | Tags: Área Clínica
@article{Takahashi2026,
title = {Diagnostic brain-to-liver [18f]fdg uptake ratio predicts survival in multiple myeloma: A retrospective study},
author = {Maria Emilia S. Takahashi and Tiago P. dos Santos and Christopher Cralcev and Eliana Miranda and Marcos Paulo D. S. Silva and Felipe C. Souza and José Barreto C. Carvalheira and Carmino A. de Souza and Celso Dario Ramos},
doi = {10.1007/s00259-026-07844-z},
issn = {1619-7089},
year = {2026},
date = {2026-03-21},
urldate = {2026-03-21},
journal = {Eur J Nucl Med Mol Imaging},
publisher = {Springer Science and Business Media LLC},
abstract = {<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>[¹⁸F]FDG PET/CT has been widely used in oncology for diagnosis and treatment monitoring. Reduced cerebral [¹⁸F]FDG uptake has been observed in patients with disseminated malignancies, potentially associated with the Warburg effect and elevated lactate levels. This study investigated the prognostic relevance of the brain-to-liver [¹⁸F]FDG uptake ratio (BLR) in MM patients who underwent PET/CT at diagnosis.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>BLR was calculated as the ratio between the mean standardized uptake value (SUV) of the whole brain and that of the liver. A total of 72 patients were retrospectively included in the study (58% male; median age 65 years (IQR55;70); 67% were classified as ISS stage III).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>
BLR, as a continuous variable, showed a statistically significant difference between groups according to sex (
<jats:italic>p</jats:italic>
= 0.004), overweight status (
<jats:italic>p</jats:italic>
= 0.005), and ISS stage (
<jats:italic>p</jats:italic>
= 0.03), and was negatively correlated with β₂-microglobulin (
<jats:italic>r</jats:italic>
= − 0.42,
<jats:italic>p</jats:italic>
< 0.001). With a median follow-up of 23 months (IQR 8; 65), 74% patients had died from MM-related causes. Patients with BLR > 2.7 demonstrated superior 60-month overall survival (52%vs.10%,
<jats:italic>p</jats:italic>
= 0.002) and progression-free survival (19%vs.3%,
<jats:italic>p</jats:italic>
= 0.003), respectively. Multivariate Cox regression confirmed BLR (HR 1.86 95%CI: 1.03–3.33,
<jats:italic>p</jats:italic>
= 0.038 (OS); HR 1.93 95%CI: 1.13–3.29,
<jats:italic>p</jats:italic>
= 0.016 (PFS))as an independent factor and the use of autologous hematopoietic cell transplantation (HCT) as consolidation for both OS and PFS. In addition, ISS stage III was also a prognostic factor for OS.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Higher brain-to-liver [¹⁸F]FDG uptake ratio (> 2.7) at diagnosis predicts better clinical outcomes in multiple myeloma. BLR is significantly associated with established clinical markers of tumor burden in multiple myeloma. These findings suggest that BLR is a feasible and reproducible metric with potential prognostic value in multiple myeloma.</jats:p>
</jats:sec>},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
<jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>[¹⁸F]FDG PET/CT has been widely used in oncology for diagnosis and treatment monitoring. Reduced cerebral [¹⁸F]FDG uptake has been observed in patients with disseminated malignancies, potentially associated with the Warburg effect and elevated lactate levels. This study investigated the prognostic relevance of the brain-to-liver [¹⁸F]FDG uptake ratio (BLR) in MM patients who underwent PET/CT at diagnosis.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>BLR was calculated as the ratio between the mean standardized uptake value (SUV) of the whole brain and that of the liver. A total of 72 patients were retrospectively included in the study (58% male; median age 65 years (IQR55;70); 67% were classified as ISS stage III).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>
BLR, as a continuous variable, showed a statistically significant difference between groups according to sex (
<jats:italic>p</jats:italic>
= 0.004), overweight status (
<jats:italic>p</jats:italic>
= 0.005), and ISS stage (
<jats:italic>p</jats:italic>
= 0.03), and was negatively correlated with β₂-microglobulin (
<jats:italic>r</jats:italic>
= − 0.42,
<jats:italic>p</jats:italic>
< 0.001). With a median follow-up of 23 months (IQR 8; 65), 74% patients had died from MM-related causes. Patients with BLR > 2.7 demonstrated superior 60-month overall survival (52%vs.10%,
<jats:italic>p</jats:italic>
= 0.002) and progression-free survival (19%vs.3%,
<jats:italic>p</jats:italic>
= 0.003), respectively. Multivariate Cox regression confirmed BLR (HR 1.86 95%CI: 1.03–3.33,
<jats:italic>p</jats:italic>
= 0.038 (OS); HR 1.93 95%CI: 1.13–3.29,
<jats:italic>p</jats:italic>
= 0.016 (PFS))as an independent factor and the use of autologous hematopoietic cell transplantation (HCT) as consolidation for both OS and PFS. In addition, ISS stage III was also a prognostic factor for OS.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Higher brain-to-liver [¹⁸F]FDG uptake ratio (> 2.7) at diagnosis predicts better clinical outcomes in multiple myeloma. BLR is significantly associated with established clinical markers of tumor burden in multiple myeloma. These findings suggest that BLR is a feasible and reproducible metric with potential prognostic value in multiple myeloma.</jats:p>
</jats:sec>
Antoniolli, Giorgio; Junior, Gilberto Carlos Franchi; Lima, Keli; de Mello Lopes, Rayssa; Barbosa, Euzebio Guimarães; Machado-Neto, João Agostinho; Lima, Carmen Silvia Passos; Rodrigues, Tiago; Coelho, Fernando
In Silico, in vitro, and in vivo studies of a 2-substituted quinazolin-4(3H)-one in T-cell acute lymphoblastic leukemia Journal Article
Em: Toxicology and Applied Pharmacology, vol. 507, 2026, ISSN: 0041-008X.
Links | BibTeX | Tags: Área Pré-Clínica
@article{Antoniolli2026,
title = {In Silico, in vitro, and in vivo studies of a 2-substituted quinazolin-4(3H)-one in T-cell acute lymphoblastic leukemia},
author = {Giorgio Antoniolli and Gilberto Carlos Franchi Junior and Keli Lima and Rayssa de Mello Lopes and Euzebio Guimarães Barbosa and João Agostinho Machado-Neto and Carmen Silvia Passos Lima and Tiago Rodrigues and Fernando Coelho},
doi = {10.1016/j.taap.2025.117667},
issn = {0041-008X},
year = {2026},
date = {2026-02-00},
urldate = {2026-02-00},
journal = {Toxicology and Applied Pharmacology},
volume = {507},
publisher = {Elsevier BV},
keywords = {Área Pré-Clínica},
pubstate = {published},
tppubtype = {article}
}
van Petten Vasconcelos Azevedo, Fernanda; Ruiz, Ana Lúcia Tasca Gois; Rodrigues, Diego Samuel; Nakahata, Douglas Hideki; de Paiva, Raphael Enoque Ferraz; de Araujo, Daniele Ribeiro; de La Via, Ana Carola; Alves, Wendel Andrade; Requena, Michelle Barreto; Kurachi, Cristina; Stringasci, Mirian Denise; Vollet-Filho, José Dirceu; Lustri, Wilton Rogério; Bagnato, Vanderlei Salvador; Abbehausen, Camilla; Corbi, Pedro Paulo; Lima, Carmen Silvia Passos
Navigating the Challenges of Metallopharmaceutical Agents: Strategies and Predictive Modeling for Skin Cancer Therapy Journal Article
Em: Pharmaceutics, vol. 18, não 2, 2026, ISSN: 1999-4923.
Resumo | Links | BibTeX | Tags: Área Pré-Clínica
@article{Azevedo2026,
title = {Navigating the Challenges of Metallopharmaceutical Agents: Strategies and Predictive Modeling for Skin Cancer Therapy},
author = {Fernanda van Petten Vasconcelos Azevedo and Ana Lúcia Tasca Gois Ruiz and Diego Samuel Rodrigues and Douglas Hideki Nakahata and Raphael Enoque Ferraz de Paiva and Daniele Ribeiro de Araujo and Ana Carola de La Via and Wendel Andrade Alves and Michelle Barreto Requena and Cristina Kurachi and Mirian Denise Stringasci and José Dirceu Vollet-Filho and Wilton Rogério Lustri and Vanderlei Salvador Bagnato and Camilla Abbehausen and Pedro Paulo Corbi and Carmen Silvia Passos Lima},
doi = {10.3390/pharmaceutics18020145},
issn = {1999-4923},
year = {2026},
date = {2026-02-00},
urldate = {2026-02-00},
journal = {Pharmaceutics},
volume = {18},
number = {2},
publisher = {MDPI AG},
abstract = {<jats:p>Skin cancer (SC) is the most prevalent malignancy worldwide, with subtypes varying in aggressiveness: basal cell carcinoma tends to be locally invasive, squamous cell carcinoma has a higher metastatic risk, and melanoma remains the deadliest form. Current treatments such as surgery, radiotherapy, and systemic chemotherapy are associated with aesthetic and functional morbidity, recurrence, and/or systemic toxicity. Although targeted therapies and immunotherapies offer clinical benefits, their high cost and limited accessibility underscore the need for innovative, affordable alternatives. Metal-based compounds (metallopharmaceuticals) are promising anticancer agents due to their ability to induce oxidative stress, modulate redox pathways, and interact with DNA. However, clinical translation has been limited by poor aqueous solubility, rapid degradation, and low skin permeability. This review discusses the most recent preclinical findings on gold, silver, platinum, palladium, ruthenium, vanadium, and copper complexes, mainly in topical and systemic treatments of SC. Advances in chemical and physical enhancers, such as hydrogels and microneedles, and in drug delivery systems, including bacterial nanocellulose membranes and nanoparticles, as well as liposomes and micelles, for enhancing skin permeation and protecting the integrity of metal complexes are also discussed. Additionally, we examine the contribution of photodynamic therapy to SC treatment and the use of mathematical and computational modeling to simulate skin drug transport, predict biodistribution, and support rational nanocarrier design. Altogether, these strategies aim to bridge the gap between physicochemical innovation and clinical applicability, paving the way for more selective, stable, and cost-effective SC treatments.</jats:p>},
keywords = {Área Pré-Clínica},
pubstate = {published},
tppubtype = {article}
}
von Zuben, Andrea Paula Bruno; de Souza, Carmino Antonio
Social inequalities in cancer incidence and mortality in Campinas, Brazil: a decade of population-based registry data (2010-2019) Journal Article
Em: International Journal of Annals Medical and Health Science, vol. 4, iss. 1, pp. 1-2, 2026.
BibTeX | Tags: Área Clínica
@article{nokey,
title = {Social inequalities in cancer incidence and mortality in Campinas, Brazil: a decade of population-based registry data (2010-2019)},
author = {Andrea Paula Bruno von Zuben and Carmino Antonio de Souza },
year = {2026},
date = {2026-01-20},
urldate = {2026-01-20},
journal = {International Journal of Annals Medical and Health Science},
volume = {4},
issue = {1},
pages = {1-2},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Torricelli, Caroline; Tobar, Natália; Sasse, André; Etchebehere, Elba
Insights from PSMAfore: impact on health-related quality of life Journal Article
Em: Transl Androl Urol, vol. 15, não 1, pp. 3–3, 2026, ISSN: 2223-4691.
Links | BibTeX | Tags: Área Clínica
@article{Torricelli2026,
title = {Insights from PSMAfore: impact on health-related quality of life},
author = {Caroline Torricelli and Natália Tobar and André Sasse and Elba Etchebehere},
doi = {10.21037/tau-2025-aw-750},
issn = {2223-4691},
year = {2026},
date = {2026-01-00},
urldate = {2026-01-00},
journal = {Transl Androl Urol},
volume = {15},
number = {1},
pages = {3--3},
publisher = {AME Publishing Company},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Mastrobuono-Cordeiro, Francisco; Nunes, Julia H. Bormio; de M. Pereira, Gabriele; Nakahata, Douglas H.; Frajácomo, Silmara C. L.; Lustri, Wilton R.; de Carvalho, João Ernesto; Pereira, Douglas H.; Ruiz, Ana Lúcia T. G.; de Paiva, Raphael E. F.; Corbi, Pedro P.
Synthesis, structural characterization and biological evaluation of silver(I) complexes with 2-thiouracil and 2,4-dithiouracil Journal Article
Em: Inorganica Chimica Acta, vol. 590, 2026, ISSN: 0020-1693.
Links | BibTeX | Tags: Área Básica
@article{Mastrobuono-Cordeiro2026,
title = {Synthesis, structural characterization and biological evaluation of silver(I) complexes with 2-thiouracil and 2,4-dithiouracil},
author = {Francisco Mastrobuono-Cordeiro and Julia H. Bormio Nunes and Gabriele de M. Pereira and Douglas H. Nakahata and Silmara C.L. Frajácomo and Wilton R. Lustri and João Ernesto de Carvalho and Douglas H. Pereira and Ana Lúcia T.G. Ruiz and Raphael E.F. de Paiva and Pedro P. Corbi},
doi = {10.1016/j.ica.2025.122971},
issn = {0020-1693},
year = {2026},
date = {2026-01-00},
urldate = {2026-01-00},
journal = {Inorganica Chimica Acta},
volume = {590},
publisher = {Elsevier BV},
keywords = {Área Básica},
pubstate = {published},
tppubtype = {article}
}
de Lacerda, Meiry Leandra; Costa, Letícia Roberta Martins; da Silva Coimbra, Dayanne Maria; de Menezes Pereira, Gabriele; Silva, Clara Maria Faria; Corbi, Pedro Paulo; Rossi, Daise Aparecida; de Oliveira Júnior, Robson José; de Melo, Roberta Torres; Guerra, Wendell
Em: Inorganica Chimica Acta, vol. 589, 2026, ISSN: 0020-1693.
Links | BibTeX | Tags: Área Básica
@article{deLacerda2026b,
title = {A new palladium(II) complex containing ethylenediamine and 2-thioxo-4-thiazolidinone exhibits high activity against resistant Campylobacter jejuni strains},
author = {Meiry Leandra de Lacerda and Letícia Roberta Martins Costa and Dayanne Maria da Silva Coimbra and Gabriele de Menezes Pereira and Clara Maria Faria Silva and Pedro Paulo Corbi and Daise Aparecida Rossi and Robson José de Oliveira Júnior and Roberta Torres de Melo and Wendell Guerra},
doi = {10.1016/j.ica.2025.122913},
issn = {0020-1693},
year = {2026},
date = {2026-01-00},
urldate = {2026-01-00},
journal = {Inorganica Chimica Acta},
volume = {589},
publisher = {Elsevier BV},
keywords = {Área Básica},
pubstate = {published},
tppubtype = {article}
}
Carron, Juliana; Ferreira, Ana Maria Castro; Carvalho, Bruna Fernandes; Lourenço, Gustavo Jacob; Lima, Carmen Silvia Passos
CTLA-4 and TNFRSF1B genetic variants in clinicopathological aspects and outcome of cutaneous melanoma Journal Article
Em: vol. 36, não 4, pp. 263–273, 2026, ISSN: 1473-5636.
Resumo | Links | BibTeX | Tags: Área Clínica
@article{Carron2026,
title = {CTLA-4 and TNFRSF1B genetic variants in clinicopathological aspects and outcome of cutaneous melanoma},
author = {Juliana Carron and Ana Maria Castro Ferreira and Bruna Fernandes Carvalho and Gustavo Jacob Lourenço and Carmen Silvia Passos Lima},
doi = {10.1097/cmr.0000000000001108},
issn = {1473-5636},
year = {2026},
date = {2026-00-00},
urldate = {2026-00-00},
volume = {36},
number = {4},
pages = {263--273},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
abstract = {<jats:sec>
<jats:title/>
<jats:p>
Cutaneous melanoma is the most aggressive form of skin cancer, influenced by environmental and genetic factors, particularly immune-related genes like cytotoxic T-lymphocyte-associated protein 4 (
<jats:italic toggle="yes">CTLA-4</jats:italic>
) and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
. We investigated the association of inherited single nucleotide variants in
<jats:italic toggle="yes">CTLA-4</jats:italic>
(rs11571316, rs62182595, rs11571315, and rs4553808) and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
(rs3397, rs1061622, rs1061624, and rs1061628) with clinicopathological aspects and survival of 428 cutaneous melanoma patients. Carriers of
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs3397 TC/CC genotypes were younger at diagnosis. The
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AA plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GG genotypes were more common in male than female patients.
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AA or rs62182595 GG plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GG were more frequent among patients with tumors on the head, neck, and trunk. Patients older than 54 years with
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs11571316 GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs3397 TT had a 3.04-times greater chance of progression to death because of tumor effects. Patients with head, neck, and trunk cutaneous melanoma carrying
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA had a 2.30-times greater chance of recurrence, progression, or tumor-related death. Patients with head, neck, and trunk cutaneous melanoma carrying
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA, and
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs62182595 GA/AA and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA genotypes had a 2.97- and 2.75-times greater chance of progression to death because of tumor effects, respectively. These findings suggest immune modulation linked to these single nucleotide variants may facilitate cutaneous melanoma progression and highlight the potential for immunotherapeutic strategies in genetically predisposed patients.
</jats:p>
</jats:sec>},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
<jats:title/>
<jats:p>
Cutaneous melanoma is the most aggressive form of skin cancer, influenced by environmental and genetic factors, particularly immune-related genes like cytotoxic T-lymphocyte-associated protein 4 (
<jats:italic toggle="yes">CTLA-4</jats:italic>
) and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
. We investigated the association of inherited single nucleotide variants in
<jats:italic toggle="yes">CTLA-4</jats:italic>
(rs11571316, rs62182595, rs11571315, and rs4553808) and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
(rs3397, rs1061622, rs1061624, and rs1061628) with clinicopathological aspects and survival of 428 cutaneous melanoma patients. Carriers of
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs3397 TC/CC genotypes were younger at diagnosis. The
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AA plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GG genotypes were more common in male than female patients.
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AA or rs62182595 GG plus
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GG were more frequent among patients with tumors on the head, neck, and trunk. Patients older than 54 years with
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs11571316 GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs3397 TT had a 3.04-times greater chance of progression to death because of tumor effects. Patients with head, neck, and trunk cutaneous melanoma carrying
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA had a 2.30-times greater chance of recurrence, progression, or tumor-related death. Patients with head, neck, and trunk cutaneous melanoma carrying
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs4553808 AG/GG and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA, and
<jats:italic toggle="yes">CTLA-4</jats:italic>
rs62182595 GA/AA and
<jats:italic toggle="yes">TNFRSF1B</jats:italic>
rs1061624 GA/AA genotypes had a 2.97- and 2.75-times greater chance of progression to death because of tumor effects, respectively. These findings suggest immune modulation linked to these single nucleotide variants may facilitate cutaneous melanoma progression and highlight the potential for immunotherapeutic strategies in genetically predisposed patients.
</jats:p>
</jats:sec>
Genaro, Livia Moreira; Carron, Juliana; Lourenço, Gustavo Jacob; Nagasako, Cristiane Kibune; Reis, Glaucia Fernanda Soares Rupert; Camargo, Michel Gardere; de Sene Portel Oliveira, Priscilla; Lima, Carmen Silvia Passos; de Lourdes Setsuko Ayrizono, Maria; de Azevedo, Anibal Tavares; Leal, Raquel Franco
Em: Pharmaceutics, vol. 17, não 12, 2025, ISSN: 1999-4923.
Resumo | Links | BibTeX | Tags: Área Clínica
@article{Genaro2025b,
title = {Interpretable Artificial Neural Network Models for Predicting Anti-Adalimumab Immune Complex and Serum Drug Level in Crohn’s Disease: A Proof-of-Concept Study},
author = {Livia Moreira Genaro and Juliana Carron and Gustavo Jacob Lourenço and Cristiane Kibune Nagasako and Glaucia Fernanda Soares Rupert Reis and Michel Gardere Camargo and Priscilla de Sene Portel Oliveira and Carmen Silvia Passos Lima and Maria de Lourdes Setsuko Ayrizono and Anibal Tavares de Azevedo and Raquel Franco Leal},
doi = {10.3390/pharmaceutics17121536},
issn = {1999-4923},
year = {2025},
date = {2025-12-00},
urldate = {2025-12-00},
journal = {Pharmaceutics},
volume = {17},
number = {12},
publisher = {MDPI AG},
abstract = {<jats:p>Background: The development of anti-drug antibodies (ADAs) and resulting immune complexes are key mechanisms behind the secondary loss of response to adalimumab in Crohn’s disease (CD). Despite their clinical importance, routine immunogenicity assays are limited, underscoring the need for alternative predictive approaches. Objective: This study aimed to develop interpretable artificial neural network (ANN) models to predict immune complex formation and estimate serum adalimumab levels using routinely available clinical and laboratory data from CD patients. Methods: A prospective analysis was performed on 58 CD patients on maintenance adalimumab. Immune complexes and serum adalimumab were measured via ELISA and lateral flow assays. ANN and ensemble regression models were trained on demographic, clinical, and inflammatory data, with performance evaluated by five-fold cross-validation. Interpretability was enhanced using Garson’s algorithm and permutation importance. Results: The ANN-based classification model accurately predicted ADA immune complex formation, achieving an accuracy of 77.47% and an area under the curve (AUC) of 82.63%. The main predictive variables included extraintestinal manifestations, perianal disease, disease behavior, and age at diagnosis. For estimating serum adalimumab levels measured by ELISA, the model performed modestly (accuracy 59.89%, AUC 79.72%), incorporating factors such as Montreal classification, perianal disease, C-reactive protein, immunosuppressant use, and disease duration. Conclusions: Interpretable ANN models robustly predict anti-adalimumab immune complexes and, to a lesser extent, serum adalimumab, using clinically available data, including perianal disease. This proof-of-concept study is limited by the relatively small, single-center dataset (n = 58), which may affect model generalizability and increase the risk of overfitting. External validation in larger and multicenter cohorts is required before clinical implementation.</jats:p>},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Souza, Stephan; Ribeiro, Felipe; Brito, Ana; Minekawa, Thaís; Lopes, Flávia; Matedi, Sumara; Fockink, Renata; Anjos, Dalton; Gomes, Gustavo; Silva, Laura; Camacho, Mariana; Santos, Allan; Araújo, Whemberton; Teixeira, Ana; Martins, Raul; Sanches, Adelina; Hanaoka, Nilton; Tavares, Rafael; Villela-Pedras, Felipe; Mourato, Felipe; Torricelli, Caroline; Alves, Thiago; Tavares, Marcelo; Lima, Mariana; Moraes, André; Sasse, André; Almeida, Paulo; Etchebehere, Elba
Brazilian profile of Radium-223 in metastatic prostate cancer: a multicentric, retrospective study Journal Article
Em: EJNMMI Rep., vol. 9, não 1, 2025, ISSN: 3005-074X.
Links | BibTeX | Tags: Área Clínica
@article{Souza2025,
title = {Brazilian profile of Radium-223 in metastatic prostate cancer: a multicentric, retrospective study},
author = {Stephan Souza and Felipe Ribeiro and Ana Brito and Thaís Minekawa and Flávia Lopes and Sumara Matedi and Renata Fockink and Dalton Anjos and Gustavo Gomes and Laura Silva and Mariana Camacho and Allan Santos and Whemberton Araújo and Ana Teixeira and Raul Martins and Adelina Sanches and Nilton Hanaoka and Rafael Tavares and Felipe Villela-Pedras and Felipe Mourato and Caroline Torricelli and Thiago Alves and Marcelo Tavares and Mariana Lima and André Moraes and André Sasse and Paulo Almeida and Elba Etchebehere},
doi = {10.1186/s41824-025-00245-9},
issn = {3005-074X},
year = {2025},
date = {2025-12-00},
urldate = {2025-12-00},
journal = {EJNMMI Rep.},
volume = {9},
number = {1},
publisher = {Springer Science and Business Media LLC},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Ramos, Celso Dario
Quantification in Clinical Nuclear Medicine: A Language Before a Number Journal Article
Em: Clinical Nuclear Medicine, 2025, ISSN: 1536-0229.
Links | BibTeX | Tags: Área Clínica
@article{Ramos2025b,
title = {Quantification in Clinical Nuclear Medicine: A Language Before a Number},
author = {Celso Dario Ramos},
doi = {10.1097/rlu.0000000000006145},
issn = {1536-0229},
year = {2025},
date = {2025-10-30},
urldate = {2025-10-30},
journal = {Clinical Nuclear Medicine},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Coelho, Maria Paula M.; de Menezes Pereira, Gabriele; Corbi, Pedro Paulo; Nakahata, Douglas H.; Gandin, Valentina; Donati, Chiara; Vecina, Juliana F.; Ruiz, Ana Lucia T. G.
Exploring biological properties of sulfa-based copper(II) complexes: in vitro genotoxicity, cytotoxicity (2D and 3D) and mechanistic insights Journal Article
Em: Biometals, vol. 38, não 5, pp. 1551–1567, 2025, ISSN: 1572-8773.
Links | BibTeX | Tags: Área Básica
@article{Coelho2025,
title = {Exploring biological properties of sulfa-based copper(II) complexes: in vitro genotoxicity, cytotoxicity (2D and 3D) and mechanistic insights},
author = {Maria Paula M. Coelho and Gabriele de Menezes Pereira and Pedro Paulo Corbi and Douglas H. Nakahata and Valentina Gandin and Chiara Donati and Juliana F. Vecina and Ana Lucia T. G. Ruiz},
doi = {10.1007/s10534-025-00719-0},
issn = {1572-8773},
year = {2025},
date = {2025-10-00},
urldate = {2025-10-00},
journal = {Biometals},
volume = {38},
number = {5},
pages = {1551--1567},
publisher = {Springer Science and Business Media LLC},
keywords = {Área Básica},
pubstate = {published},
tppubtype = {article}
}
Ramos, Celso Dario
Redefining Nuclear Medicine: “Biodistribution” Should Be the Core Concept Journal Article
Em: J Nucl Med, vol. 66, não 9, pp. 1498–1498, 2025, ISSN: 2159-662X.
Links | BibTeX | Tags: Área Clínica
@article{Ramos2025,
title = {Redefining Nuclear Medicine: “Biodistribution” Should Be the Core Concept},
author = {Celso Dario Ramos},
doi = {10.2967/jnumed.125.270245},
issn = {2159-662X},
year = {2025},
date = {2025-09-00},
urldate = {2025-09-00},
journal = {J Nucl Med},
volume = {66},
number = {9},
pages = {1498--1498},
publisher = {Society of Nuclear Medicine},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Carrilho, Larissa Ariel Oliveira; Guerra, Livia Dias; de Lellis Moreira, Rafaella Caroline; Juliani, Fabiana Lascala; Santos, Fernanda Silva; de Holanda Padilha, Daniela Morais; Zaperlão, Fabíola Furtuoso; Branbilla, Sandra Regina; Horita, Vivian Naomi; Novaes, Davi Magalhães Leite; Antunes-Correa, Lígia Moraes; Lima, Carmem Silvia Passos; Mendes, Maria Carolina Santos; Carvalheira, José Barreto Campello
Prognostic impact of low muscularity in metastatic and recurrent head and neck cancer: Insights from C3-based assessments Journal Article
Em: Clinical Nutrition ESPEN, vol. 68, pp. 767–773, 2025, ISSN: 2405-4577.
Links | BibTeX | Tags: Área Clínica
@article{Carrilho2025b,
title = {Prognostic impact of low muscularity in metastatic and recurrent head and neck cancer: Insights from C3-based assessments},
author = {Larissa Ariel Oliveira Carrilho and Livia Dias Guerra and Rafaella Caroline de Lellis Moreira and Fabiana Lascala Juliani and Fernanda Silva Santos and Daniela Morais de Holanda Padilha and Fabíola Furtuoso Zaperlão and Sandra Regina Branbilla and Vivian Naomi Horita and Davi Magalhães Leite Novaes and Lígia Moraes Antunes-Correa and Carmem Silvia Passos Lima and Maria Carolina Santos Mendes and José Barreto Campello Carvalheira},
doi = {10.1016/j.clnesp.2025.06.029},
issn = {2405-4577},
year = {2025},
date = {2025-08-00},
urldate = {2025-08-00},
journal = {Clinical Nutrition ESPEN},
volume = {68},
pages = {767--773},
publisher = {Elsevier BV},
keywords = {Área Clínica},
pubstate = {published},
tppubtype = {article}
}
Nakahata, Douglas H.; de M. Pereira, Gabriele; Ribeiro, Marcos A.; Oliveira, Igor S.; de Oliveira Moreira, Josélia C.; Pontes, Robson; de Carvalho, João E.; Ruiz, Ana Lucia T. G.; Farrell, Nicholas P.; Corbi, Pedro P.
Pd(II) complexes of 4-(2-aminoethyl)benzenesulfonamide Schiff bases: Structure, DNA binding and antiproliferative activity Journal Article
Em: Inorganica Chimica Acta, vol. 581, 2025, ISSN: 0020-1693.
Links | BibTeX | Tags: Área Básica
@article{Nakahata2025,
title = {Pd(II) complexes of 4-(2-aminoethyl)benzenesulfonamide Schiff bases: Structure, DNA binding and antiproliferative activity},
author = {Douglas H. Nakahata and Gabriele de M. Pereira and Marcos A. Ribeiro and Igor S. Oliveira and Josélia C. de Oliveira Moreira and Robson Pontes and João E. de Carvalho and Ana Lucia T.G. Ruiz and Nicholas P. Farrell and Pedro P. Corbi},
doi = {10.1016/j.ica.2025.122659},
issn = {0020-1693},
year = {2025},
date = {2025-06-00},
urldate = {2025-06-00},
journal = {Inorganica Chimica Acta},
volume = {581},
publisher = {Elsevier BV},
keywords = {Área Básica},
pubstate = {published},
tppubtype = {article}
}





